Evidence map›Paper›PMID 35530592›Full record

ArticleRSC advances2019

Effects of linker and liposome anchoring on lactose-functionalized glycomacromolecules as multivalent ligands for binding galectin-3.

Tanja Freichel, Dominic Laaf, Miriam Hoffmann, Patrick B Konietzny, Viktoria Heine, Robert Wawrzinek, Christoph Rademacher, Nicole L Snyder, Lothar Elling, Laura Hartmann

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Synthesis of Galectin Inhibitors by Regioselective 3'-Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Tanja FreichelDepartment of Organic and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany laura.hartmann@hhu.de +49-211-81-15840 +49-211-81-10360.
Dominic LaafLaboratory for Biomaterials, Institute for Biotechnology, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Pauwelsstraße 20 52074 Aachen Germany.
Miriam HoffmannDepartment of Organic and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany laura.hartmann@hhu.de +49-211-81-15840 +49-211-81-10360.
Patrick B KonietznyDepartment of Organic and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany laura.hartmann@hhu.de +49-211-81-15840 +49-211-81-10360.
Viktoria HeineLaboratory for Biomaterials, Institute for Biotechnology, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Pauwelsstraße 20 52074 Aachen Germany.
Robert WawrzinekMax Planck Institute of Colloids and Interfaces Mühlenberg 1 14424 Potsdam Germany.
Christoph RademacherMax Planck Institute of Colloids and Interfaces Mühlenberg 1 14424 Potsdam Germany.ORCID https://orcid.org/0000-0001-7082-7239
Nicole L SnyderDepartment of Chemistry, Davidson College North Carolina 28035 USA.ORCID https://orcid.org/0000-0002-2508-4090
Lothar EllingLaboratory for Biomaterials, Institute for Biotechnology, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Pauwelsstraße 20 52074 Aachen Germany.ORCID https://orcid.org/0000-0002-3654-0397
Laura HartmannDepartment of Organic and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany laura.hartmann@hhu.de +49-211-81-15840 +49-211-81-10360.ORCID https://orcid.org/0000-0003-0115-6405
Heinrich Heine University Düsseldorf · DEInstitute for Biomedical Engineering · CHMax Planck Institute of Colloids and Interfaces · DEDavidson College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we present a bottom-up approach for the synthesis of lactose-functionalized glycomacromolecules and glycofunctionalized liposomes and apply these compounds to investigate their effects of multivalent presentation on binding to galectin-3. Step-wise assembly of tailor-made building blocks on solid supports was used to synthesize a series of oligo(amidoamine) scaffolds that were further conjugated to lactose

Identifiers

PMID35530592
PMCPMC9069326
OpenAlexW2966377928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.