ArticleRegenerative engineering and translational medicine2021
The Mechanism of Metallosis After Total Hip Arthroplasty.
Article in Regenerative engineering and translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cobalt-Induced Cardiomyopathy: Mitochondrial Dysfunction, Oxidative Stress, and Reversible Cardiac Toxicity: A Systematic Review.Cardiovascular toxicology · 2026Pooled it
- Severe Metallosis after Tumor Mega-Prosthesis: Revise or Retain? - A Case Series.Journal of orthopaedic case reports · 2026Article
- Wire-stem fretting and galvanic corrosion as an underrecognized cause of metallosis after hip arthroplasty: A rare case report.Joint diseases and related surgery · 2026Article
- "Squeaky Hip": Are Noises Important?Arthroplasty today · 2026Article
- Article
- Presence of Metallosis Can Interfere With Culture Positivity in Prosthetic Joint Infection of the Hip.Arthroplasty today · 2025Article
- Selenium nanoparticles alleviate cobalt toxicity in artificial joint metal prostheses by inhibiting ferroptosis through activation of the PRDX6/GPX4 pathway.Materials today. Bio · 2025Article
- Structural influence on titanium ion dissolution in 3D-printed Ti6Al4V orthopedic implants.Scientific reports · 2025Article
- Biocomposite-Based Biomimetic Plate for Alternative Fixation of Proximal Humerus Fractures.Biomimetics (Basel, Switzerland) · 2025Article
- Outcomes following primary total hip arthroplasty with ceramic-on-metal and metal-on-metal bearings.Archives of orthopaedic and trauma surgery · 2025Observational
- Article
- Evaluating the potential hepatotoxicity from hip implant wear products-AnBiomaterials and biosystems · 2025Article
- Comparison of blood metal ion levels in scoliosis patients following instrumented spinal fusion with cobalt-chromium and titanium alloy rods.Scientific reports · 2025Article
- Biomechanical Impact of Cementation Technique Variations on Femoral Stem Stability: An In Vitro Polyurethane Model Study.Journal of clinical medicine · 2025Article
- Metallosis after anatomic total shoulder arthroplasty resulting from contact with retained metallic suture anchors: a case report.JSES reviews, reports, and techniques · 2025Article
- Engineering the Immune Response to Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- The Journey of an Ankylosed Hip: A 20 Year Long-Term Follow-up of an Hip Arthrodesis using Cobra Plate - The Present Day Relevance.Journal of orthopaedic case reports · 2024Article
- Review
- Metallosis Following Non-Metal-on-Metal Hip Arthroplasty: A Case Report and Review.Journal of orthopaedic case reports · 2024Article
- Elevated Titanium Levels After Revision Total Hip Caused by Previously Unreported Mechanism.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Metallosis is defined as the accumulation and deposition of metallic particles secondary to abnormal wear from prosthetic implants that may be visualized as abnormal macroscopic staining of periprosthetic soft tissues. This phenomenon occurs secondary to the release of metal ions and particles from metal-on-metal hip implants in patients with end-stage osteoarthritis. Ions and particles shed from implants can lead to local inflammation of surrounding tissue and less commonly, very rare systemic manifestations may occur in various organ systems. With the incidence of total hip arthroplasty increasing as well as rates of revisions due to prosthesis failure from previous metal-on-metal implants, metallosis has become an important area of research. Bodily fluids are electrochemically active and react with biomedical implants. Particles, especially cobalt and chromium, are released from implants as they abrade against one another into the surrounding tissues. The body's normal defense mechanism becomes activated, which can elicit a cascade of events, leading to inflammation of the immediate surrounding tissues and eventually implant failure. In this review, various mechanisms of metallosis are explored. Focus was placed on the atomic and molecular makeup of medical implants, the component/surgical associated factors, cellular responses, wear, tribocorrosion, joint loading, and fluid pressure associated with implantation. Current treatment guidelines for failed implants include revision surgery. An alternative treatment could be chelation therapy, which may drive future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.