Evidence map›Paper›PMID 35530371›Full record

ArticleSymmetry2021

Structure and Interdigitation of Chain-Asymmetric Phosphatidylcholines and Milk Sphingomyelin in the Fluid Phase.

Moritz P K Frewein, Milka Doktorova, Frederick A Heberle, Haden L Scott, Enrico F Semeraro, Lionel Porcar, Georg Pabst

Open access · goldAbstract read
In one paragraph

Article in Symmetry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Moritz P K FreweinInstitute of Molecular Biosciences, University of Graz, NAWI Graz, 8010 Graz, Austria.ORCID 0000-0002-0329-5305
Milka DoktorovaDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.ORCID 0000-0003-4366-2242
Frederick A HeberleDepartment of Chemistry, University of Tennessee Knoxville, Knoxville, TN 37996, USA.ORCID 0000-0002-0424-3240
Haden L ScottCenter for Environmental Biotechnology, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0002-5778-4905
Enrico F SemeraroInstitute of Molecular Biosciences, University of Graz, NAWI Graz, 8010 Graz, Austria.ORCID 0000-0002-6096-1108
Lionel PorcarInstitut Laue-Langevin, 38043 Grenoble, France.ORCID 0000-0003-4674-7591
Georg PabstInstitute of Molecular Biosciences, University of Graz, NAWI Graz, 8010 Graz, Austria.ORCID 0000-0003-1967-1536
University of Graz · ATInstitut Laue-Langevin · FROak Ridge National Laboratory · USUniversity of Tennessee at Knoxville · USUniversity of Virginia · US

Funding

Coupling of lateral and transverse organization in complex biomembranesR01GM138887 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI HEBERLE, FREDERICK A, WAXHAM, M. NEAL · 2020 to 2023
$1.7M
Transient loss of plasma membrane asymmetry in mammalian cells: mechanisms and functionF32GM134704 · NIGMS · UNIVERSITY OF VIRGINIA · PI DOKTOROVA, MILKA · 2020 to 2022
$204k
NIGMS NIH HHS F32 GM134704NIGMS NIH HHS R01 GM138887
6 · The paper itself

Abstract

We addressed the frequent occurrence of mixed-chain lipids in biological membranes and their impact on membrane structure by studying several chain-asymmetric phosphatidylcholines and the highly asymmetric milk sphingomyelin. Specifically, we report trans-membrane structures of the corresponding fluid lamellar phases using small-angle X-ray and neutron scattering, which were jointly analyzed in terms of a membrane composition-specific model, including a headgroup hydration shell. Focusing on terminal methyl groups at the bilayer center, we found a linear relation between hydrocarbon chain length mismatch and the methyl-overlap for phosphatidylcholines, and a non-negligible impact of the glycerol backbone-tilting, letting the

Indexed as

MD simulationsmixed-chain lipidsneutron scatteringX-ray scattering

Identifiers

PMID35530371
PMCPMC9075682
OpenAlexW3173830284

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.