Evidence map›Paper›PMID 35530273›Full record

ArticleAmerican journal of cancer research2022

Everolimus combined with 5-aza-2-deoxycytidine generated potent anti-tumor effects on ovarian clear cell cancer stem-like/spheroid cells by inhibiting the COL6A3-AKT-mTOR pathway.

Chih-Ming Ho, Fa-Kung Lee, Ting-Lin Yen, Shih-Hung Huang, Wen-Fang Cheng

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chih-Ming HoGynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital Taipei, Taiwan.
Fa-Kung LeeGynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital Taipei, Taiwan.
Ting-Lin YenDepartment of Medical Research, Cathay General Hospital New Taipei, Taiwan.
Shih-Hung HuangDepartment of Pathology, Cathay General Hospital Taipei, Taiwan.
Wen-Fang ChengDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University Taipei, Taiwan.
National Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian clear cell cancer stem-like/spheroid cells (OCCCSCs) were associated with recurrence, metastasis, and chemoresistance in ovarian clear cell carcinoma (OCCC). We evaluated the anti-tumor effects of 5-aza-2-deoxycytidine (5-aza-dC) combined with everolimus (RAD001) on human OCCC. We investigated parental OCCCSCs and paclitaxel-resistant cell lines derived from OCCCSCs

Indexed as

5-aza-2-deoxycytidinecancer stem cellsCOL6A3-AKT-mTOR pathwayeverolimusovarian cancerovarian clear cell

Identifiers

PMID35530273
PMCPMC9077075
OpenAlexW4285742278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.