ArticleJACC. Basic to translational science2022
Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics.
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Article in JACC. Basic to translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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26citing papers in PubMed, 2 pooled it
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Cellular senescence in acute human infectious disease: a systematic review.Frontiers in aging · 2024Pooled it
- Prognostic value of von Willebrand factor and ADAMTS13 in patients with COVID-19: A systematic review and meta-analysis.Thrombosis research · 2022Pooled it
- Computational proteomics to enhance personalized treatment of COVID-19 and Long COVID.Clinical proteomics · 2026Review
- Musculoskeletal Complications in COVID-19: Exploring the Role of Key Biomarkers.International journal of molecular sciences · 2025Review
- Effects of Cytokines (or Activating Factors) on Arterial Endothelial Cells.International journal of molecular sciences · 2025Review
- KLK8: charting new territories in left ventricular hypertrophy biomarker research.Biomarkers in medicine · 2025Article
- Exploration of the plasma proteomic profile of patients at risk of thromboembolic events.Research and practice in thrombosis and haemostasis · 2025Article
- Proteomic changes upon treatment with semaglutide in individuals with obesity.Nature medicine · 2025Article
- Geroscience in heart failure: the search for therapeutic targets in the shared pathobiology of human aging and heart failure.The journal of cardiovascular aging · 2025Article
- Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients.Biomolecules · 2024Article
- Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes.Science advances · 2024Article
- Plasma Proteins Associated with COVID-19 Severity in Puerto Rico.International journal of molecular sciences · 2024Article
- Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human.Science translational medicine · 2024Article
- Predictors and Clinical Significance of Myocardial Injury in Elderly Patients Under the COVID-19 Pandemic.International journal of general medicine · 2024Article
- Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID.Frontiers in cardiovascular medicine · 2024Review
- Association between loss of hypercoagulable phenotype, clinical features and complement pathway consumption in COVID-19.Frontiers in immunology · 2024Observational
- Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity.Frontiers in immunology · 2024Article
- NADNitric oxide : biology and chemistry · 2023Article
- Activation of coagulation and proinflammatory pathways in thrombosis with thrombocytopenia syndrome and following COVID-19 vaccination.Nature communications · 2023Article
- A large-scale genome-wide cross-trait analysis for the effect of COVID-19 on female-specific cancers.iScience · 2023Article
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Authors and funding
23 authors at 6 institutions in 1 country.
Jason D RohCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Robert R KitchenCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
J Sawalla GusehCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jenna N McNeillDivision of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Malika AidCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Amanda J MartinotCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Andy YuCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Colin PlattCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
James RheeCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Brittany WeberDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Lena E TragerCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Margaret H HastingsCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sarah DucatDepartment of Biomedical Sciences, Section of Pathology, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, USA.
Peng XiaCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Claire CastroCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Abhilasha SinghCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Bjarni AtlasonCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Timothy W ChurchillCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Marcelo F Di CarliDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Patrick T EllinorCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Dan H BarouchCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Jennifer E HoCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Anthony RosenzweigCorrigan Minehan Heart Center, Division of Cardiology, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Harvard University · USMassachusetts General Hospital · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USRagon Institute of MGH, MIT and Harvard · USTufts University · US
Funding
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MUnderstanding the Cardiac Benefits of Exercise at the Cellular and Molecular LevelR35HL155318 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANTHONY ROSENZWEIG · 2021 to 2026
$5.4MAFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1MEicosanoid Profiles as Determinants of HFpEFR01HL140224 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2018 to 2021
$3.1MRole of Activin Type II receptor signaling in age-related heart failureR01AG061034 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSENZWEIG, ANTHONY · 2019 to 2023
$3.0MThe Association of Metabolic Disease and Pulmonary HypertensionR01HL134893 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2017 to 2021
$2.9MMentoring in Arrhythmia ResearchK24HL105780 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2011 to 2020
$1.2MActivin type II receptor activity in age-related frailty and heart failureK76AG064328 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI ROH, JASON DAVID · 2019 to 2022
$972kThe Role of Family with Sequence Similarity 3D (FAM3D) in Cardioprotection and Inflammation after Myocardial InfarctionK08HL140200 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RHEE, JAMES · 2019 to 2023
$864kMentoring in Patient-Oriented and Translational HFpEF ResearchK24HL153669 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jennifer E Ho · 2020 to 2026
$744kDigital pathology for defining myeloid cell-mediated lung injury during acute SARS CoV-2 Infection in hamstersR21AI166743 · NIAID · TUFTS UNIVERSITY BOSTON · PI MARTINOT, AMANDA, TZIPORI, SAUL R · 2022 to 2023
$454kNHLBI NIH HHS K08 HL140200NHLBI NIH HHS K24 HL105780NHLBI NIH HHS K24 HL153669NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL134893NHLBI NIH HHS R01 HL140224NHLBI NIH HHS R35 HL155318NIAID NIH HHS R21 AI166743NIA NIH HHS K76 AG064328NIA NIH HHS R01 AG061034
Abstract
To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator of senescence-promoting Activin/TGFβ signaling, and ADAMTS13, the von Willebrand Factor-cleaving protease whose loss-of-function causes microvascular thrombosis, were among the proteins most strongly associated with myocardial stress and injury. Findings were validated in a larger COVID-19 patient cohort and the hamster COVID-19 model, providing new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications.
Indexed as
ADAMTS13, A Disintegrin And Metalloproteinase with a Thrombospondin type 1 motif, member 13COVID-19FSTL3, follistatin-like 3hsTnT, high sensitivity troponin Tmyocardial injuryNT-proBNP, N-terminal pro–B-type natriuretic peptideproteomicsSASP, senescence associated secretory phenotypesenescenceTGFβ, transforming growth factor beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.