Evidence map›Paper›PMID 35530160›Full record

ArticleActa pharmaceutica Sinica. B2022

Chiral mesoporous silica nano-screws as an efficient biomimetic oral drug delivery platform through multiple topological mechanisms.

Yumei Wang, Jia Ke, Xianmou Guo, Kaijun Gou, Zhentao Sang, Yanbu Wang, Yan Bian, Sanming Li, Heran Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yumei WangDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jia KeDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xianmou GuoDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Kaijun GouDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhentao SangSchool of Pharmacy, China Medical University, Shenyang 110122, China.
Yanbu WangDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yan BianSchool of Pharmacy, China Medical University, Shenyang 110122, China.
Sanming LiDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Heran LiSchool of Pharmacy, China Medical University, Shenyang 110122, China.
Shenyang Pharmaceutical University · CNChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the microscale, bacteria with helical body shapes have been reported to yield advantages in many bio-processes. In the human society, there are also wisdoms in knowing how to recognize and make use of helical shapes with multi-functionality. Herein, we designed atypical chiral mesoporous silica nano-screws (CMSWs) with ideal topological structures (

Indexed as

APTES, 3-aminopropyltriethoxysilaneAR, aspect ratioAUC0‒∞, area under the curveCd, drug loading capacityChiral mesoporous silicaCmax, maximum concentrationCMSRs, chiral mesoporous silica nanorodsCMSs, chiral mesoporous silicas nanoparticlesCMSSs, chiral mesoporous silica nanospheresCMSWs, chiral mesoporous silica nano-screwsDAPI, 4,6-diamidino-2-phenylindoleDCM, dichloromethaneDOX, doxorubicinEDC·HCl, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochlorideFBS, fetal bovine serumFITC, Fluorescein isothiocyanateFrel, relative bioavailabilityGeometric topological structureGI, gastrointestinalHOBT, 1-hydroxybenzotriazoleIEB, intestinal epithelium barrierIntestinal epithelium barrierIR, infrared spectroscopyMorphologyMRT0‒∞, mean residence timeMSNs, mesoporous silica nanoparticlesMβ-CD, methyl-β-cyclodextrinnano-DDS, nano-drug delivery systemsNano-screwN-PLA, N-palmitoyl-l-alanineNPs, nanoparticlesOral adsorptionPBS, phosphate buffer solutionRBCs, red blood cellsRITC, rhodamine B isothiocyanateSARS-CoV-2, severe acute respiratory syndrome coronavirus 2SBET, Specific surface areaSBF, simulated body fluidSD, Sprague–DawleySGF, simulated gastric fluidSIF, simulated intestinal fluidt1/2, half-lifeTEOS, ethylsilicateTmax, peak timeVt, pore volumeWBJH, pore diameterXRD, X-ray diffractometry

Identifiers

PMID35530160
PMCPMC9072246
OpenAlexW3195014193

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.