ArticleFrontiers in immunology2022
Inborn Errors of Immunity in Algerian Children and Adults: A Single-Center Experience Over a Period of 13 Years (2008-2021).
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Clinical and Immunological Features, Genetic Variants, and Outcomes of Patients with CD40 Deficiency.Journal of clinical immunology · 2023Pooled it
- Inborn Errors of Immunity Genotype: A Retrospective Study from the United Arab Emirates.Journal of clinical immunology · 2026Article
- Diagnostic utility of targeted flow cytometry in genetically confirmed inborn errors of immunity: a 20-year single-center experience.Frontiers in immunology · 2026Article
- Clinical and genetic spectrum of inborn errors of immunity: a retrospective study on outcomes at a single center.Frontiers in immunology · 2026Article
- Autoimmune manifestations in children with inborn errors of immunity in Morocco: A study from the national registry.Journal of translational autoimmunity · 2025Article
- The Spectrum of Bacterial Infection in a Large Cohort of Chinese Pediatric Patients with Inborn Errors of Immunity: A Nine-year, Retrospective, Single-center Study.Journal of clinical immunology · 2025Article
- Monogenic Common Variable Immunodeficiency (Mo-CVID) Score for Optimizing the Genetic Diagnosis in Pediatric CVID Cohort.European journal of immunology · 2025Article
- Contribution of next generation sequencing to the diagnosis of inborn errors of immunity in a pediatric cohort.Frontiers in immunology · 2025Article
- Burden of rare genetic disorders in India: twenty-two years' experience of a tertiary centre.Orphanet journal of rare diseases · 2024Article
- Inborn Errors of Immunity in Jordan: First Report from a Tertiary Referral Center.Journal of clinical immunology · 2024Article
- Inborn Errors of Immunity-the Sri Lankan Experience 2010-2022.Journal of clinical immunology · 2023Article
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Authors and funding
109 authors at 20 institutions in 5 countries.
Brahim BelaidDepartment of Medical Immunology, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Lydia Lamara MahammedDepartment of Medical Immunology, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Ouardia DraliDepartment of Pediatrics B, Hussein Dey University Hospital Center, University of Algiers 1, Algiers, Algeria.
Aida Mohand OussaidDepartment of Pediatrics A, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Nabila Souad TouriDepartment of Pediatrics, Blida University Hospital Center, University of Blida, Blida, Algeria.
Souhila MelziDepartment of Pediatrics, Bab El Oued University Hospital Center, University of Algiers 1, Algiers, Algeria.
Abdelhak DehimiDepartment of Pediatrics, Setif University Hospital Center, University of Setif 1, Setif, Algeria.
Lylia Meriem BerkaniDepartment of Medical Immunology, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Fatma MerahDepartment of Medical Immunology, Beni Messous University Hospital Center, Algiers, Algeria.
Zineb LarabDepartment of Medical Immunology, Beni Messous University Hospital Center, Algiers, Algeria.
Ines AllamDepartment of Medical Immunology, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Ouarda KhemiciDepartment of Pediatrics B, Beni Messous University Hospital Center, Algiers, Algeria.
Sonya Yasmine KiraneDepartment of Pediatrics B, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Mounia BoutabaDepartment of Pediatrics A, Hussein Dey University Hospital Center, University of Algiers 1, Algiers, Algeria.
Reda BelbouabDepartment of Pediatrics, Mustapha Pacha University Hospital Center, University of Algiers 1, Algiers, Algeria.
Hadjira BekkakchaDepartment of Pediatrics A, Hussein Dey University Hospital Center, University of Algiers 1, Algiers, Algeria.
Assia GuedouarDepartment of Pediatrics A, Hussein Dey University Hospital Center, University of Algiers 1, Algiers, Algeria.
Abdelhakim ChelaliDepartment of Pediatrics, Djelfa Public Hospital Institution, Djelfa, Algeria.
Brahim BaamaraDepartment of Pediatrics, Djelfa Public Hospital Institution, Djelfa, Algeria.
Djamila NouiDepartment of Pediatrics, Batna University Hospital center, University of Batna, Batna, Algeria.
Hadda BaazizDepartment of Pediatrics, Batna University Hospital center, University of Batna, Batna, Algeria.
Radia RezakDepartment of Pediatric Gastroenterology and Nutrition, Canastel Children's Hospital, Oran, Algeria.
Sidi Mohamed AzzouzDepartment of Pediatric Gastroenterology and Nutrition, Canastel Children's Hospital, University of Oran, Oran, Algeria.
Malika AichaouiDepartment of Pediatric Pneumo-Allergology, Canastel Children's Hospital, Oran, Algeria.
Assia MoktefiDepartment of Pediatric Pneumo-Allergology, Canastel Children's Hospital, Oran, Algeria.
Redha Mohamed BenhatchiDepartment of Pediatric Pneumo-Allergology, Canastel Children's Hospital, Oran, Algeria.
Meriem OussalahDepartment of Pediatric Pneumo-Allergology, Canastel Children's Hospital, University of Oran, Oran, Algeria.
Naila BenaissaDepartment of Children's Infectious Diseases, Canastel Children's Hospital, University of Oran, Oran, Algeria.
Amel LaredjDepartment of Children's Infectious Diseases, Canastel Children's Hospital, University of Oran, Oran, Algeria.
Assia BouchetaraDepartment of Children's Infectious Diseases, Canastel Children's Hospital, University of Oran, Oran, Algeria.
Abdelkader AdriaDepartment of Pediatric Hematology, Canastel Children's Hospital, Oran, Algeria.
Brahim HabirecheDepartment of Pediatrics, El Bayadh Public Hospital Institution, EL Bayadh, Algeria.
Noureddine TounsiDepartment of Pediatrics, El Bayadh Public Hospital Institution, EL Bayadh, Algeria.
Fella DahmounDepartment of Pediatrics, Bejaia University Hospital Center, University of Bejaia, Bejaia, Algeria.
Rabah TouatiDepartment of Pediatrics, Bejaia University Hospital Center, University of Bejaia, Bejaia, Algeria.
Hamza BoucennaDepartment of Pediatrics A, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Fadila BouferouaDepartment of Pediatrics A, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Lynda SekfaliDepartment of Pediatrics A, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Nadjet BouhafsDepartment of Pediatrics, Bab El Oued University Hospital Center, University of Algiers 1, Algiers, Algeria.
Rawda AbouraDepartment of Pediatrics, Bab El Oued University Hospital Center, University of Algiers 1, Algiers, Algeria.
Sakina KherraDepartment of Pediatrics A, Hussein Dey University Hospital Center, University of Algiers 1, Algiers, Algeria.
Yacine InouriDepartment of Pediatrics, Central Hospital of the Army, University of Algiers 1, Algiers, Algeria.
Saadeddine DibDepartment of Pediatrics, Mother & Child Hospital of Tlemcen, University of Tlemcen, Tlemcen, Algeria.
Nawel MedouriDepartment of Pediatrics, Saida Public Hospital Institution, Saida, Algeria.
Noureddine KhelfaouiDepartment of Pediatrics, Saida Public Hospital Institution, Saida, Algeria.
Aicha RedjedalDepartment of Pediatrics, Saida Public Hospital Institution, Saida, Algeria.
Amara ZelaciDepartment of Pediatrics, El Oued Public Hospital Institution, El Oued, Algeria.
Samah YahiaouiDepartment of Pediatrics, Barika Public Hospital Institution, Batna, Algeria.
Sihem MedjadjDepartment of Pediatrics, Ghardaia Public Hospital Institution, Ghardaia, Algeria.
Tahar Khelifi TouhamiPrivate Practitioner, Constantine, Algeria.
Ahmed KadiDepartment of Pneumology A, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Fouzia AmirecheDepartment of Pediatrics, Mother & Child Hospital of EL Mansourah, University of Constantine 3, Constantine, Algeria.
Imane FradaDepartment of Pediatrics, Biskra Public Hospital Institution, Biskra, Algeria.
Shahrazed HouasniaDepartment of Pediatrics, El Harrouche Public Hospital Institution, Skikda, Algeria.
Karima BenarabDepartment of Pediatrics, Tizi Ouzou University Hospital Center, University of Tizi Ouzou, Tizi Ouzou, Algeria.
Chahynez BoubidiDepartment of Pediatrics A, Hussein Dey University Hospital Center, University of Algiers 1, Algiers, Algeria.
Yacine FerhaniDepartment of Pediatrics, Mustapha Pacha University Hospital Center, University of Algiers 1, Algiers, Algeria.
Hayet BenaliouaDepartment of Pediatrics, Mustapha Pacha University Hospital Center, University of Algiers 1, Algiers, Algeria.
Samia SokhalDepartment of Pediatrics, Mustapha Pacha University Hospital Center, University of Algiers 1, Algiers, Algeria.
Nadia BenamarDepartment of Pediatrics, Tighennif Public Hospital Institution, Mascara, Algeria.
Samira AggouneDepartment of Pediatrics, El-Harrach Public Hospital Institution, University of Algiers 1, Algiers, Algeria.
Karima HadjiDepartment of Pediatrics, Ain Oulmene Public Hospital Institution, Setif, Algeria.
Asma BelloutiDepartment of Pediatrics, Ain Azel Public Hospital Institution, Setif, Algeria.
Hakim RahmouneDepartment of Pediatrics, Setif University Hospital Center, University of Setif 1, Setif, Algeria.
Nada BoutridDepartment of Pediatrics, Setif University Hospital Center, University of Setif 1, Setif, Algeria.
Kamelia OkkaDepartment of Pediatrics, Setif University Hospital Center, University of Setif 1, Setif, Algeria.
Assia AmmourDepartment of Pediatrics, Mother & Child Hospital of Touggourt, Touggourt, Algeria.
Houssem SaadouneDepartment of Pneumology, Mila Public Hospital Institution, Mila, Algeria.
Malika AmrounDepartment of Pediatrics, Central Hospital of the Army, University of Algiers 1, Algiers, Algeria.
Hayet BelhadjDepartment of Pediatrics, Central Hospital of the Army, University of Algiers 1, Algiers, Algeria.
Amina GhanemDepartment of Pediatrics, Khenchela Public Hospital Institution, Khenchela, Algeria.
Hanane AbbazDepartment of Pediatrics, Khenchela Public Hospital Institution, Khenchela, Algeria.
Sana BoudriouaDepartment of Pediatrics, El Khroub Public Hospital Institution, Constantine, Algeria.
Besma ZebicheDepartment of Pediatrics, Kolea Public Hospital Institution, Tipaza, Algeria.
Assia AyadDepartment of Pediatrics, Kolea Public Hospital Institution, Tipaza, Algeria.
Zahra HamadacheDepartment of Pediatrics, Kolea Public Hospital Institution, Tipaza, Algeria.
Nassima OuarasDepartment of Infectious Diseases, EL Kettar Specialized Hospital, University of Algiers 1, Algiers, Algeria.
Nassima AchourDepartment of Infectious Diseases, EL Kettar Specialized Hospital, University of Algiers 1, Algiers, Algeria.
Nadira BouchairDepartment of Pediatrics, Annaba University Hospital Center, University of Annaba, Annaba, Algeria.
Houda BoudiafDepartment of Pediatric Oncology, Mustapha pacha University Hospital Center, University of Algiers 1, Algiers, Algeria.
Dahila Bekkat-BerkaniDepartment of Pediatrics, Bologhine Public Hospital Institution, University of Algiers 1, Algiers, Algeria.
Hachemi MaoucheDepartment of Pediatrics, El-Harrach Public Hospital Institution, University of Algiers 1, Algiers, Algeria.
Zahir BouzrarDepartment of Pediatrics, Bab El Oued University Hospital Center, University of Algiers 1, Algiers, Algeria.
Lynda AissatDepartment of Pediatrics, Mother & Child Hospital of Tipaza, University of Blida, Algiers, Algeria.
Ouardia IbsaineDepartment of Pediatrics, Ain Taya Public Hospital Institution, University of Algiers 1, Algiers, Algeria.
Belkacem BioudDepartment of Pediatrics, Setif University Hospital Center, University of Setif 1, Setif, Algeria.
Leila KedjiDepartment of Pediatrics, Blida University Hospital Center, University of Blida, Blida, Algeria.
Djazia DahloukDepartment of Pediatrics, Central Hospital of the Army, University of Algiers 1, Algiers, Algeria.
Manoubia BensminaDepartment of Pediatrics B, Douera University Hospital Center, University of Blida, Algiers, Algeria.
Abdelkarim RadouiDepartment of Pediatric Pneumo-Allergology, Canastel Children's Hospital, University of Oran, Oran, Algeria.
Mimouna BessahraouiDepartment of Pediatric Gastroenterology and Nutrition, Canastel Children's Hospital, University of Oran, Oran, Algeria.
Nadia BensaadiDepartment of Pediatrics, Tizi Ouzou University Hospital Center, University of Tizi Ouzou, Tizi Ouzou, Algeria.
Azzeddine MekkiDepartment of Pediatrics B, Hussein Dey University Hospital Center, University of Algiers 1, Algiers, Algeria.
Zoulikha ZeroualDepartment of Pediatrics A, Hussein Dey University Hospital Center, University of Algiers 1, Algiers, Algeria.
Koon-Wing ChanDepartment of Pediatrics and Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Daniel LeungDepartment of Pediatrics and Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Amar TebaibiaDepartment of Internal Medicine, El Biar Public Hospital Institution, University of Algiers 1, Algiers, Algeria.
Soraya AyoubDepartment of Internal Medicine, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Dalila MekidecheDepartment of Pneumology B, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Merzak GharnaoutDepartment of Pneumology A, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Jean Laurent CasanovaLaboratory of Human Genetics of Infectious Diseases, Necker Hospital for Sick Children, INSERM UMR 1163, Paris, France.
Anne PuelLaboratory of Human Genetics of Infectious Diseases, Necker Hospital for Sick Children, INSERM UMR 1163, Paris, France.
Yu Lung LauDepartment of Pediatrics and Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Nacira CherifDepartment of Pediatrics B, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Samir LadjDepartment of Pediatrics, El Biar Public Hospital Institution, University of Algiers 1, Algiers, Algeria.
Leila SmatiDepartment of Pediatrics, Bologhine Public Hospital Institution, University of Algiers 1, Algiers, Algeria.
Rachida BoukariDepartment of Pediatrics, Mustapha Pacha University Hospital Center, University of Algiers 1, Algiers, Algeria.
Nafissa BenhallaDepartment of Pediatrics A, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
Reda DjidjikDepartment of Medical Immunology, Beni Messous University Hospital Center, University of Algiers 1, Algiers, Algeria.
University of Algiers Benyoucef Benkhedda · DZUniversité Oran 1 Ahmed Ben Bella · DZCentre Hospito Universitaire de Sétif · DZUniversity Hospital of Oran · DZUniversity of Algiers 3 · DZUniversity of Blida · DZUniversité de Saida Dr.Moulay Tahar · DZUniversity of Batna 1 · DZAbbès Laghrour University of Khenchela · DZCentre Universitaire Nour Bachir El Bayadh · DZMouloud Mammeri University of Tizi-Ouzou · DZUniversity of Béjaïa · DZUniversity of Hong Kong · HKZiane Achour University of Djelfa · DZBadji Mokhtar University · DZCentre Hospitalo-Universitaire Bab El Oued · DZCentre Universitaire de Mila · DZChinese University of Hong Kong · CNInstitut des Maladies Génétiques Imagine · FRRockefeller University · US
Funding
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MGenome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasisR01AI127564 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Anne Puel · 2017 to 2026
$4.8MGenome-Wide Dissection of Mendelian Susceptibility to Mycobacterial DiseaseR01AI095983 · NIAID · ROCKEFELLER UNIVERSITY · PI BUSTAMANTE, JACINTA, CASANOVA, JEAN-LAURENT · 2021 to 2025
$2.5MHoward Hughes Medical InstituteNCATS NIH HHS UL1 TR001866NIAID NIH HHS R01 AI095983NIAID NIH HHS R01 AI127564
Abstract
Background: Inborn errors of immunity (IEI) predispose patients to various infectious and non-infectious complications. Thanks to the development and expanding use of flow cytometry and increased awareness, the diagnostic rate of IEI has markedly increased in Algeria the last decade. Aim: This study aimed to describe a large cohort of Algerian patients with probable IEI and to determine their clinical characteristics and outcomes. Methods: We collected and analyzed retrospectively the demographic data, clinical manifestations, immunologic, genetic data, and outcome of Algerian IEI patients - diagnosed in the department of medical immunology of Beni Messous university hospital center, Algiers, from 2008 to 2021. Results: Eight hundred and seven patients with IEI (482 males and 325 females) were enrolled, 9.7% of whom were adults. Consanguinity was reported in 50.3% of the cases and a positive family history in 32.34%. The medium age at disease onset was 8 months and at diagnosis was 36 months. The median delay in diagnosis was 16 months. Combined immunodeficiencies were the most frequent (33.8%), followed by antibody deficiencies (24.5%) and well-defined syndromes with immunodeficiency (24%). Among 287 patients tested for genetic disorders, 129 patients carried pathogenic mutations; 102 having biallelic variants mostly in a homozygous state (autosomal recessive disorders). The highest mortality rate was observed in patients with combined immunodeficiency (70.1%), especially in patients with severe combined immunodeficiency (SCID), Omenn syndrome, or Major Histocompatibility Complex (MHC) class II deficiency. Conclusion: The spectrum of IEI in Algeria is similar to that seen in most countries of the Middle East and North Africa (MENA) region, notably regarding the frequency of autosomal recessive and/or combined immunodeficiencies.
Indexed as
Immunologic Deficiency SyndromesPrimary Immunodeficiency DiseasesSevere Combined ImmunodeficiencyAdultAlgeriaChildFemaleHumansMaleRetrospective StudiesAlgeriaclinical featuresdiagnosisepidemiologyinborn errors of immunitymolecular diagnosisprimary immunodeficiency
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