Evidence map›Paper›PMID 35529519›Full record

ArticleCerebral cortex communications2022

Phasic stimulation in the nucleus accumbens enhances learning after traumatic brain injury.

Joshua P Aronson, Husam A Katnani, Anna Huguenard, Graham Mulvaney, Edward R Bader, Jimmy C Yang, Emad N Eskandar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Joshua P AronsonDepartment of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, United States.ORCID https://orcid.org/0000-0001-5300-0010
Husam A KatnaniDepartment of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, United States.ORCID https://orcid.org/0000-0002-1688-7190
Anna HuguenardDepartment of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, United States.ORCID https://orcid.org/0000-0002-8625-4698
Graham MulvaneyDepartment of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, United States.ORCID https://orcid.org/0000-0002-9884-9015
Edward R BaderDepartment of Neurological Surgery, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Rose F. Kennedy Center, Bronx, NY, 10461, United States.ORCID https://orcid.org/0000-0003-2762-4414
Jimmy C YangDepartment of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, United States.ORCID https://orcid.org/0000-0003-1995-5926
Emad N EskandarDepartment of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, United States.ORCID https://orcid.org/0000-0002-0682-2625
Harvard University · USAlbert Einstein College of Medicine · USDartmouth–Hitchcock Medical Center · US

Funding

CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patientsUL1TR002556 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, KIM, MIMI Y · 2018 to 2022
$26.7M
NCATS NIH HHS UL1 TR002556
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide. Despite improvements in survival, treatments that improve functional outcome remain lacking. There is, therefore, a pressing need to develop novel treatments to improve functional recovery. Here, we investigated task-matched deep-brain stimulation of the nucleus accumbens (NAc) to augment reinforcement learning in a rodent model of TBI. We demonstrate that task-matched deep brain stimulation (DBS) of the NAc can enhance learning following TBI. We further demonstrate that animals receiving DBS exhibited greater behavioral improvement and enhanced neural proliferation. Treated animals recovered to an uninjured behavioral baseline and showed retention of improved performance even after stimulation was stopped. These results provide encouraging early evidence for the potential of NAc DBS to improve functional outcomes following TBI and that its effects may be broad, with alterations in neurogenesis and synaptogenesis.

Indexed as

deep brain stimulationlearningmicrostimulationnucleus accumbenstraumatic brain injury

Identifiers

PMID35529519
PMCPMC9070350
OpenAlexW4223555157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.