Evidence map›Paper›PMID 35529508›Full record

ArticleInternational journal of preventive medicine2022

Methylation and Polymorphism in CDH1 Gene Promoter Among Patients with Diffuse Gastric Cancer.

Mohadeseh Naghi Vishteh, Mehrdad Zeinalian, Majid Kheirollahi, Amirreza Javadi Mamaghani, Mohammad Ali Zolfaghari, Aliyar Mirzapour, Meisam Barati, Seyed Javad Seyed Tabaei

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In one paragraph

Article in International journal of preventive medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Medeniyet medical journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Mohadeseh Naghi VishtehDepartment of Genetics & Molecular biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mehrdad ZeinalianDepartment of Genetics & Molecular biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Majid KheirollahiDepartment of Genetics & Molecular biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Amirreza Javadi MamaghaniDepartment of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Ali ZolfaghariDepartment of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Aliyar MirzapourDepartment of Parasitology and Mycology, School of Medcine Islamic Azad University Mashhad Branch, Mashhad, Iran.
Meisam BaratiDepartment of Cellular and Molecular Nutrition, Shahid Beheshti University of Medical, Tehran, Iran.
Seyed Javad Seyed TabaeiDepartment of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Isfahan University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IRIslamic Azad University, Mashhad · IRTabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The promoter methylation and single nucleotide polymorphisms (SNPs) affect the transcription activity of cancer-related genes in several cancers including diffuse gastric cancer (DGC). Here we aimed to evaluate the promoter methylation status and the rs16260 at the promoter region of the CDH1 gene in DGC. Methods: This case-control study was performed of 48 formalin-fixed paraffin-embedded (FFPE) blocks of DGC patients and 41 fresh frozen tissue samples of healthy individuals. Methylation status was evaluated using methylation-specific polymerase chain reaction (PCR) and the rs16260 at the promoter region of the CDH1 gene was assessed using PCR and sequencing method. Results: The occurrence of methylation at the promoter region of the CDH1 gene in DGC patients was significantly higher than control samples ( Conclusions: Here we showed that methylation at the CDH1 promoter may contribute to the DGC development, and also the AC genotype was associated with the risk of DGC.

Indexed as

Cadherin 1methylationpolymerase chain reactionsequence analysisstomach neoplasms

Identifiers

PMID35529508
PMCPMC9069152
OpenAlexW4226412121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.