SynthesisFrontiers in nutrition2022
Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients.
Synthesis in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Prevalence and prognosis of sarcopenia in acute COVID-19 and long COVID: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Prevalence of Sarcopenia in Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Impact of SARS-CoV-2 Infection on Pulmonary Function in the PURE-Colombia Cohort: A Comparative Analysis with Pre-COVID Values and Non-COVID-19 Controls.Journal of clinical medicine · 2026Article
- CT-defined muscle density as a prognostic factor in multiple myeloma undergoing autologous stem cell therapy: a retrospective single center study.Journal of cancer research and clinical oncology · 2024Article
- Dual-Energy CT muscle fat fraction as a new imaging biomarker of body composition and survival predictor in critically ill patients.European radiology · 2024Article
- Article
- Association of excess visceral fat and severe illness in hospitalized COVID-19 patients in Japan: a retrospective cohort study.International journal of obesity (2005) · 2024Article
- A new bio imagery user-friendly tool for automatic morphometry measurement on muscle cell cultures and histological sections.Scientific reports · 2024Article
- New Insights into the Effects of SARS-CoV-2 on Metabolic Organs: A Narrative Review of COVID-19 Induced Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Post-COVID-19 condition: systemic inflammation and low functional exercise capacity.Frontiers in nutrition · 2024Article
- Dynapenia and Sarcopenia in Post-COVID-19 Syndrome Hospitalized Patients Are Associated with Severe Reduction in Pulmonary Function.Journal of clinical medicine · 2023Article
- Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women.Journal of the American Geriatrics Society · 2023Article
- The Effects of a Pulmonary Rehabilitation Program in Severe and Critical COVID-19 Disease: A Prospective Observational Study.Journal of clinical practice and research · 2023Article
- Visceral to subcutaneous fat ratio predicts short-term mortality in patients with Covid 19. A multicenter study.The British journal of radiology · 2023Article
- Editorial: Systemic markers of muscle loss.Frontiers in nutrition · 2023Article
- [Coronavirus disease 2019 and frailty].Zeitschrift fur Gerontologie und Geriatrie · 2022Review
- Prognostic Impact of Myosteatosis on Mortality in Hospitalized Patients with COVID-19.Diagnostics (Basel, Switzerland) · 2022Article
- Ultrasonographic findings in long COVID: A cross-sectional study of 312 patients.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COVID-19 caused by SARS-CoV-2 infection is a highly contagious disease affecting both the higher and lower portions of the respiratory tract. This disease reached over 265 million people and has been responsible for over 5.25 million deaths worldwide. Skeletal muscle quality and total mass seem to be predictive of COVID-19 outcome. This systematic review aimed at providing a critical analysis of the studies published so far reporting on skeletal muscle mass in patients with COVID-19, with the intent of examining the eventual association between muscle status and disease severity. A meta-analysis was performed to evaluate whether skeletal muscle quantity, quality and function were related to disease severity. Systematic reviews and meta-analyses were conducted according to the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions and reported according to the guidelines of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guide. From a total of 1,056 references found, 480 were selected after removing duplicates. Finally, only 7 met the specified inclusion criteria. The results of this meta-analysis showed that skeletal muscle quality, rather than quantity, was associated with COVID-19 severity, as confirmed by lower skeletal muscle density and lower handgrip strength in patients with severe disease. Muscle function assessment can thus be a valuable tool with prognostic value in COVID-19.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.