Evidence map›Paper›PMID 35529359›Full record

ArticleRSC advances2019

A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment.

Mohamed Fathi Sanad, Ahmed Esmail Shalan, Shereen Magdy Bazid, Esraa Samy Abu Serea, Elhussein M Hashem, Shimaa Nabih, Md Ariful Ahsan

Abstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohamed Fathi SanadBasic Science Departments, Modern Academy for Engineering and Technology Maadi Egypt.
Ahmed Esmail ShalanCentral Metallurgical Research and Development Institute (CMRDI) P.O. Box 87 Helwan Cairo 11421 Egypt a.shalan133@gmail.com.ORCID https://orcid.org/0000-0002-3424-1609
Shereen Magdy BazidDepartments of Biochemistry, Faculty of Science, Mansoura University Mansoura Egypt.
Esraa Samy Abu SereaChemistry & Biochemistry Department, Faculty of Science, Cairo University Cairo Egypt.
Elhussein M HashemChemistry Department, Faculty of Science, Ain-Shams University Abbasia Cairo Egypt.
Shimaa NabihBasic Science Departments, Modern Academy for Engineering and Technology Maadi Egypt.
Md Ariful AhsanThe University of Texas at El Paso 500 W University Ave El Paso TX 79968 USA mfsanad@miners.utep.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is no doubt that cancer is now one of the most formidable diseases in the world; despite all the efforts and research, common treatment routes, including chemotherapy, photodynamic therapy, and photothermal therapy, suffer from different limitations in terms of their efficiency and performance. For this reason, different strategies are being explored to improve the efficiency of the traditional drugs reported to date. In this study, we have redirected the function of one of these drugs (5-fluorouracil, 5-FU) by combining it with a graphene-gold nanocomposite in different molar ratios that has been exceedingly used for biological research development. The high activity of the graphene-gold material enables it to produce reactive oxygen and ions, which display good anticancer and antioxidant activity through the scavenging of the DPPH, SOD and GP

Identifiers

PMID35529359
PMCPMC9072570

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.