ReviewRSC advances2019
Natural source, bioactivity and synthesis of benzofuran derivatives.
Review in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed.
- Green synthesis of pyridine-benzofuran hybrids with anti-inflammatory activity alongsideiScience · 2026Article
- Ephedplics E-I: three lignans and two benzofuran-type compounds from the roots of Ephedra sinica Stapf and their neuroprotective activity.Journal of natural medicines · 2026Article
- Atroposelective Dearomative Cross-Coupling of Benzofuran Derivatives by Z-Selective Functionalization of the Vinyl C─O Bond.Angewandte Chemie (International ed. in English) · 2026Article
- Ortho-Alkynyl Quinone Methides as Privileged Intermediates in Synthesis of Polycyclic Frameworks: A Short Review.Chemical record (New York, N.Y.) · 2026Review
- Characterization of the biosynthetic enzymes of theScience advances · 2026Article
- Mulberrofuran A: A Multifunctional 2-Arylbenzofuran Flavonoid-Insights into Pharmacological Actions, Molecular Mechanisms, and Therapeutic Potential.Molecules (Basel, Switzerland) · 2026Review
- Design and Synthesis of Benzofuran-1,4-dihydropyridine Hybrids as Novel Anti-Inflammatory Agents: Theoretical Exploration of a Potential Dual COX-2/TNF-α Mechanism.Chemistry & biodiversity · 2026Article
- Visible Light-Mediated Synthesis of Chalcogen-Decorated 2,3-Dihydrobenzofurans in the Absence of Photocatalyst and Oxidants.ACS omega · 2026Article
- Novel Propofol Analogs: Design, Synthesis and Evaluation of Dihydrobenzofuran Derivatives as General Anesthetics.Pharmaceuticals (Basel, Switzerland) · 2026Article
- 2-Arylbenzofurans as Selective Cholinesterase Inhibitors: Design, Synthesis, and Evaluation as Alzheimer's Disease Agents.Biomolecules · 2026Article
- Cationic Cascade Strategy for the Synthesis of Dihydrobenzofuran and Isochromane Scaffolds.Organic letters · 2026Article
- Recent Advances in the Therapeutic Prospective of Heterocyclic Derivatives as COX-2 Inhibitors (2019-Present).Mini reviews in medicinal chemistry · 2026Review
- Review
- Unprecedented Copper/Iron-Cocatalyzed Homocoupling of Propargyl Ethers to Conjugated Benzofurans.JACS Au · 2025Article
- 7-Methoxybenzofuran-triazole tetheredRSC advances · 2025Article
- Chemodivergent C-to-N atom swap from benzofurans to benzisoxazoles and benzoxazoles.Chemical science · 2025Article
- Anticancer Potential of Halogen Derivatives of Methyl 6-Acetyl-5-Hydroxy-2-Methyl-1-Benzofuran-3-Carboxylate.International journal of molecular sciences · 2025Article
- Article
- Research Progress on Phytochemicals from Mulberry with Neuroprotective Effects: A Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Synthesis of fluorinated 3-aminobenzofuransRSC advances · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Benzofuran compounds are a class of compounds that are ubiquitous in nature. Numerous studies have shown that most benzofuran compounds have strong biological activities such as anti-tumor, antibacterial, anti-oxidative, and anti-viral activities. Owing to these biological activities and potential applications in many aspects, benzofuran compounds have attracted more and more attention of chemical and pharmaceutical researchers worldwide, making these substances potential natural drug lead compounds. For example, the recently discovered novel macrocyclic benzofuran compound has anti-hepatitis C virus activity and is expected to be an effective therapeutic drug for hepatitis C disease; novel scaffold compounds of benzothiophene and benzofuran have been developed and utilized as anticancer agents. Novel methods for constructing benzofuran rings have been discovered in recent years. A complex benzofuran derivative is constructed by a unique free radical cyclization cascade, which is an excellent method for the synthesis of a series of difficult-to-prepare polycyclic benzofuran compounds. Another benzofuran ring constructed by proton quantum tunneling has not only fewer side reactions, but also high yield, which is conducive to the construction of complex benzofuran ring systems. This review summarizes the recent studies on the various aspects of benzofuran derivatives including their important natural product sources, biological activities and drug prospects, and chemical synthesis, as well as the relationship between the bioactivities and structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.