Evidence map›Paper›PMID 35528969›Full record

ReviewJournal of clinical and translational hepatology2022

Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science.

Yasser Fouad, Melissa Palmer, Minjun Chen, Arie Regev, Rajarshi Banerjee, Rob Myers, Robert Riccio, Richard Torstenson, Ramy Younes, Puneet S Arora and 12 more

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of clinical and translational hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. MAFLD: How is it different from NAFLD?Clinical and molecular hepatology · 2023
    Review
  6. Review
  7. Article
  8. MAFLD: what 2 years of the redefinition of fatty liver disease has taught us.Therapeutic advances in endocrinology and metabolism · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 11 institutions in 5 countries.

Yasser FouadDepartment of Gastroenterology, Hepatology, and Endemic Medicine, Faculty of Medicine, Minia University, Minia, Egypt.
Melissa PalmerGannex/Ascletis Pharma Co Ltd, Beijing, China.
Minjun ChenDivision of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA.
Arie RegevEli Lilly and Company, Indianapolis, IN, USA.
Rajarshi BanerjeePerspectum Diagnostics Ltd, Oxford, UK.
Rob MyersGilead Sciences Inc, Foster City, CA, USA.
Robert RiccioSyneos Health LLC, Morrisville, NC, USA.
Richard TorstensonAllergan Marlow International, Buckinghamshire, UK.
Ramy YounesBoehringer Ingelheim International, GmbH, Ingelheim, Germany.
Puneet S AroraGenentech, Inc, South San Francisco, CA, USA.
Henrik LandgrenAbbVie, Marlow, Buckinghamshire, UK.
Morten A KarsdalNordic Bioscience A/S, Herlev, Denmark.
Martin BlakeResonance Health, Burswood, WA, Australia.
David A ShapiroIntercept Pharmaceuticals Inc, San Diego, CA, USA.
Hans-Juergen GrussSyneos Health LLC, Morrisville, NC, USA.
Muhammad Y SheikhFresno Clinical Research Center, Fresno, CA, USA.
Dina AttiaGastroenterology and Hepatology Department, Beni-Suef University, Beni Suef, Egypt.
Steven BollipoDepartment of Gastroenterology and Endoscopy, John Hunter Hospital, Newcastle, NSW, Australia.
Alastair D SmithSyneos Health LLC, Morrisville, NC, USA.
Bradley FreilichKansas City Research Institute, Kansas City, MO, USA.
Robert G GishDivision of Gastroenterology and Hepatology, Loma Linda University, Loma Linda, CA, USA.
Detlef SchuppanInstitute of Translational Immunology and Research Center for Immune Therapy, University Medical Center, Mainz, Germany.
AbbVie (United Kingdom) · GBAllergan (United Kingdom) · GBBoehringer Ingelheim (Germany) · DEEli Lilly (United States) · USGilead Sciences (United States) · USHarvard University · USJohn Hunter Hospital · AUKansas City Research Institute · USLoma Linda University · USNational Center for Toxicological Research · USNordic Bioscience (Denmark) · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic (dysfunction)-associated fatty liver disease (MAFLD) affects a third of the population and is a leading cause of liver-related death. Since no effective treatments exist, novel approaches to drug development are required. Unfortunately, outdated terminology and definitions of the disease are hampering efforts to develop new drugs and treatments. An international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease (NAFLD) to MAFLD, including a proposal for how the disease should be diagnosed. As allies with the many stakeholders in MAFLD care-including patients, patients' advocates, clinicians, researchers, nurse and allied health groups, regional societies, and others-we are aware of the negative consequences of the

Indexed as

Fatty liver diseaseFibrosisLiverMAFLDNAFLDNASH

Identifiers

PMID35528969
PMCPMC9039717
OpenAlexW3210478373

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.