Evidence map›Paper›PMID 35528963›Full record

ArticleRSC advances2015

Surface modification of neural electrodes with pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo.

J Y Lee, Z Z Khaing, J J Siegel, C E Schmidt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

J Y LeeDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Z Z KhaingDepartment of Biomedical Engineering, The University of Florida at Gainesville, Gainesville, FL, USA.
J J SiegelCenter for Learning and Memory, The University of Texas at Austin, Austin, TX, USA.
C E SchmidtDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Gainesville Obstetrics & Gynecology · USGwangju Institute of Science and Technology · KRThe University of Texas at Austin · USUniversity of Florida · US

Funding

fMRI BOLD contrast relationship to cerebrovascular toneR01EB002449 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PARRISH, TODD B · 2003 to 2006
$1.5M
Fabrication of Novel Biomimetic Polymers Using Combinatorial Peptide ScreeningR01EB004529 · NIBIB · UNIVERSITY OF TEXAS AUSTIN · PI SCHMIDT, CHRISTINE E · 2005 to 2008
$1.0M
NIBIB NIH HHS R01 EB002449NIBIB NIH HHS R01 EB004529
6 · The paper itself

Abstract

Surface of neural probes were electrochemically modified with a non-cell adhesive and biocompatible conjugate, pyrrole-hyaluronic acid (PyHA), to reduce reactive astrogliosis. Poly(PyHA)-modified wire electrodes were implanted into rat motor cortices for three weeks and were found to markedly reduce the expression of glial fibrillary acidic protein compared to uncoated electrodes.

Identifiers

PMID35528963
PMCPMC9075707
OpenAlexW2050199566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.