ArticleRSC advances2019
Retracted Article: Long non-coding RNA PCAT1 facilitates cell growth in multiple myeloma through an MTDH-mediated AKT/β-catenin signaling pathway by sponging miR-363-3p.
Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Baseline lncRNA PCAT1 high expression and its longitude increment during induction therapy predict worse prognosis in multiple myeloma patients.Journal of clinical laboratory analysis · 2021Article
Corrections and comments
- Retracted
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple Myeloma (MM) is a plasma cell myeloma. Long non-coding RNA (lncRNA) prostate cancer associated transcript 1 (PCAT1) has been identified as being associated with various types of cancer. However, the mechanism of PCAT1 was still undefined in MM. In the current study, PCAT1 and metadherin (MTDH) were up-regulated and miR-363-3p was down-regulated in MM bone marrow plasma and cells. Furthermore, PCAT1 knockdown inhibited cell proliferation, cell cycle progression, and the protein kinase B (AKT) and β-catenin signaling pathway, but induced cell apoptosis by regulating MTDH. PCAT1 was verified to sponge miR-363-3p, and MTDH was identified as a candidate target of miR-363-3p. Meanwhile, PCAT1 positively modulated MTDH expression by sponging miR-363-3p. In addition, PCAT1 knockdown blocked xenograft tumor growth
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.