Evidence map›Paper›PMID 35528784›Full record

ArticleEuropean urology open science2022

Learning Curve Analysis for Intracorporeal Robot-assisted Radical Cystectomy: Results from the EAU Robotic Urology Section Scientific Working Group.

Carl J Wijburg, Gerjon Hannink, Charlotte T J Michels, Philip C Weijerman, Rami Issa, Andrea Tay, Karel Decaestecker, Peter Wiklund, Abolfazl Hosseini, Ashwin Sridhar and 9 more

Abstract read
In one paragraph

Article in European urology open science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Carl J WijburgDepartment of Urology, Rijnstate Hospital, Arnhem, The Netherlands.
Gerjon HanninkDepartment of Operating Rooms, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Charlotte T J MichelsDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Philip C WeijermanDepartment of Urology, Rijnstate Hospital, Arnhem, The Netherlands.
Rami IssaDepartment of Urology, St. George's University Hospitals, London, UK.
Andrea TayDepartment of Urology, St. George's University Hospitals, London, UK.
Karel DecaesteckerDepartment of Urology, University Hospital Gent, Gent, Belgium.
Peter WiklundDepartment of Urology, Mount Sinai Hospital, New York, NY, USA.
Abolfazl HosseiniDepartment of Urology, Karolinska University Hospital, Stockholm, Sweden.
Ashwin SridharDepartment of Urology, University College London Hospitals, London, UK.
John KellyDepartment of Urology, University College London Hospitals, London, UK.
Frederiek d'HondtDepartment of Urology, Onze Lieve Vrouw Hospital, Aalst, Belgium.
Alexandre MottrieDepartment of Urology, Onze Lieve Vrouw Hospital, Aalst, Belgium.
Sjoerd KlaverDepartment of Urology, Maasstad Hospital, Rotterdam, The Netherlands.
Sebastian EdelingDepartment of Urology, Vinzenz Hospital, Hannover, Germany.
Paolo Dell'OglioDepartment of Urology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Francesco MontorsiDepartment of Urology, Division of Oncology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
Maroeska M RoversDepartment of Operating Rooms, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
J Alfred WitjesDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The utilisation of robot-assisted radical cystectomy with intracorporeal reconstruction (iRARC) has increased in recent years. Little is known about the length of the learning curve (LC) for this procedure. Objective: To study the length of the LC for iRARC in terms of 90-d major complications (MC90; Clavien-Dindo grade ≥3), 90-d overall complications (OC90, Clavien-Dindo grades 1-5), operating time (OT), estimated blood loss (EBL), and length of hospital stay (LOS). Design setting and participants: This was a retrospective analysis of all consecutive iRARC cases from nine European high-volume hospitals with ≥100 cases. All patients had bladder cancer for which iRARC was performed, with an ileal conduit or neobladder as the urinary diversion. Outcome measurements and statistical analysis: Outcome parameters used as a proxy for LC length were the number of consecutive cases needed to reach a plateau level in two-piece mixed-effects models for MC90, OC90, OT, EBL, and LOS. Results and limitations: A total of 2186 patients undergoing iRARC between 2003 and 2018were included. The plateau levels for MC90 and OC90 were reached after 137 cases (95% confidence interval [CI] 80-193) and 97 cases (95% CI 41-154), respectively. The mean MC90 rate at the plateau was 14% (95% CI 7-21%). The plateau level was reached after 75 cases (95% CI 65-86) for OT, 88 cases (95% CI 70-106) for EBL, and 198 cases (95% CI 130-266) for LOS. A major limitation of the study is the difference in the balance of urinary diversion types between centres. Conclusions: This multicentre retrospective analysis for the iRARC LC among nine European centres showed that 137 consecutive cases were needed to reach a stable MC90 rate. Patient summary: We carried out a multicentre analysis of the surgical learning curve for robot-assisted removal of the bladder and bladder reconstruction in patients with bladder cancer. We found that 137 consecutive cases were needed to reach a stable rate of serious complications.

Indexed as

Bladder cancerComplicationsIntracorporealLearning curveRadical cystectomyRobot-assisted

Identifiers

PMID35528784
PMCPMC9068730

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.