Evidence map›Paper›PMID 35528741›Full record

ArticleFrontiers in neurology2022

Elevations in Tumor Necrosis Factor Alpha and Interleukin 6 From Neuronal-Derived Extracellular Vesicles in Repeated Low-Level Blast Exposed Personnel.

Katie A Edwards, Jacqueline J Leete, Ethan G Smith, Alycia Quick, Claire M Modica, Eric M Wassermann, Elena Polejaeva, Kristine C Dell, Matthew LoPresti, Peter Walker and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 2 countries.

Katie A EdwardsBiomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Jacqueline J LeeteBiomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Ethan G SmithBiomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Alycia QuickSchool of Psychology, University of Glasgow, Glasgow, United Kingdom.
Claire M ModicaNaval Medical Research Center, Silver Spring, MD, United States.
Eric M WassermannNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Elena PolejaevaVA San Diego Healthcare System, San Diego, CA, United States.
Kristine C DellDepartment of Psychology, Pennsylvania State University, University Park, PA, United States.
Matthew LoPrestiCenter for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Peter WalkerJoint Artificial Intelligence Center, Arlington, VA, United States.
Meghan O'BrienDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
Chen LaiBiomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Bao-Xi QuBiomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Christina DevotoBiomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Walter CarrCenter for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
James R StoneDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
Stephen T AhlersNaval Medical Research Center, Operational and Undersea Medicine Directorate, Silver Spring, MD, United States.
Jessica M GillBiomarkers of Trauma, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
National Institutes of Health · USNational Institute of Nursing Research · USNaval Medical Research Command · USUniversity of Virginia · USWalter Reed Army Institute of Research · USAllen Institute for Artificial Intelligence · USPennsylvania State University · USUniversity of Glasgow · GBVA San Diego Healthcare System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The purpose of this pilot study was to determine if military service members with histories of hundreds to thousands of low-level blast exposures (i. e., experienced breachers) had different levels of serum and neuronal-derived extracellular vesicle (EV) concentrations of interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNFα), compared to matched controls, and if these biomarkers related to neurobehavioral symptoms. Methods: Participants were experienced breachers ( Results: Serum TNFα concentrations were decreased in breachers when compared to control concentrations ( Conclusions: These findings suggest that exposure of personnel to high numbers of low-level blast over a career may result in enduring central inflammation that is associated with chronic neurological symptoms. The data also suggest that peripheral markers of inflammation are not necessarily adequate surrogates for central neuroinflammation.

Indexed as

blastbreacherextracellular vesiclesmilitaryneuroinflammation

Identifiers

PMID35528741
PMCPMC9070565
OpenAlexW4224295012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.