ArticleFrontiers in neurology2022
Association Between Aneurysmal Hemodynamics and Rupture Risk of Unruptured Intracranial Aneurysms.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Systematic evaluation of neuro-ophthalmic outcomes of the ophthalmic artery covered by flow-diverter.Frontiers in neurology · 2025Review
- Intra-Aneurysmal High-Resolution 4D MR Flow Imaging for Hemodynamic Imaging Markers in Intracranial Aneurysm Instability.AJNR. American journal of neuroradiology · 2024Article
- Knowledge domain and emerging trends in the rupture risk of intracranial aneurysms research from 2004 to 2023.World journal of clinical cases · 2024Article
- Body composition and rupture risk of intracranial aneurysms.European journal of medical research · 2024Article
- Exploring the hemodynamic behavior of residual aneurysms after coiling and clipping: A computational flow dynamic analysis.Surgical neurology international · 2024Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Assessing rupture risk in patients with unruptured intracranial aneurysms (UIAs) remains challenging. Hemodynamics plays an important role in the natural history of intracranial aneurysms. This study aimed to compare aneurysmal hemodynamic features between patients with different rupture risk as determined by PHASES score. Methods: We retrospectively examined 238 patients who harbored a solitary saccular UIA. Patients were stratified by rupture risk into low-, intermediate-, and high-risk groups according to PHASES score. Flow simulations were performed to compare differences in hemodynamics among the groups. Results: Aneurysmal time-averaged wall shear stress (WSSa) and normalized WSS (WSSn) decreased progressively as PHASES score increased. WSSa and WSSn significantly differed among the low-, intermediate-, and high-risk groups ( Conclusions: Low WSS was significantly associated with higher risk of intracranial aneurysm rupture as determined by PHASES score, indicating that hemodynamics may play an important role in aneurysmal rupture. In the future, a multidimensional rupture risk prediction model that includes hemodynamic parameters should be investigated.
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