ArticleNature aging2022
Age-associated impairment of T cell immunity is linked to sex-dimorphic elevation of N-glycan branching.
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Article in Nature aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity.npj aging · 2026Review
- Comparative organ-wide analysis of age-related N-glycan alterations in mice reveals a link to lysosomal glycosidases.npj aging · 2026Article
- N-glycan signatures of immunoglobulins-depleted serum proteins in colorectal cancer.Glycoconjugate journal · 2026Article
- Integrative Omics Reveal Female-Specific Benefits of p16Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- SIRT3-SUMO regulated Treg cell differentiation and asthma development by mediating N-glycosylation through the FAO pathway.Cell biology and toxicology · 2025Article
- Age-related remodeling of the sialoglycans dampens murine CD8Science advances · 2025Article
- Glycosylation in neuroinflammation: mechanisms, implications, and therapeutic strategies for neurodegenerative diseases.Translational neurodegeneration · 2025Review
- Sex Differences in Immune Responses to Infectious Diseases: The Role of Genetics, Hormones, and Aging.Diseases (Basel, Switzerland) · 2025Review
- Single cell-resolved cellular, transcriptional, and epigenetic changes in mouse T cell populations linked to age-associated immune decline.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy.Aging and disease · 2025Review
- N-Glycan Branching Regulates BTLA Opposite to PD-1 to Limit T Cell Hyperactivity Induced by Branching Deficiency.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Genetics of glycosylation in mammalian development and disease.Nature reviews. Genetics · 2024Review
- Review
- Membrane organization by tetraspanins and galectins shapes lymphocyte function.Nature reviews. Immunology · 2024Review
- The 3 I's of immunity and aging: immunosenescence, inflammaging, and immune resilience.Frontiers in aging · 2024Review
- Review
- N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial.Journal of neuroinflammation · 2023Article
- Review
- T cell senescence by N-glycan branching.Aging · 2022Article
- CD73 Promotes Chronic Lymphocytic Leukemia.Cancers · 2022Article
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 2 countries.
Haik Mkhikian *Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-4560-306X
Ken L Hayama *Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Khachik KhachikyanDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Carey LiDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Raymond W ZhouDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Judy PawlingLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Suzi KlausDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Phuong Q N TranDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Kim M LyDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Andrew D GongDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Hayk SaryanDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Jasper L HaiDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
David GrigoryanDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Philip L LeeDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Barbara L NewtonDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Manuela RaffatelluDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-6487-4215
James W DennisLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-0295-5877
Michael DemetriouDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA. mdemetri@uci.edu.ORCID http://orcid.org/0000-0001-8547-5774
University of California, Irvine · USMount Sinai Hospital · CALa Jolla Institute for Immunology · US
Funding
Regulation of B cell function in demyelinating disease by N-glycan branchingR01AI144403 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI DEMETRIOU, MICHAEL · 2019 to 2023
$2.5MImpaired T cell immunity in the Elderly via enhanced N-glycosylation.R01AI108917 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI DEMETRIOU, MICHAEL · 2014 to 2018
$2.3MMechanisms of human immune modulation by oral N-acetylglucosamineR01AT007452 · NCCIH · UNIVERSITY OF CALIFORNIA-IRVINE · PI DEMETRIOU, MICHAEL · 2014 to 2018
$2.0MNutritional immunity during Salmonella infectionR01AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAFFATELLU, MANUELA · 2016 to 2020
$1.9MDevelopment of siderophore-based vaccines against non-typhoidal Salmonella infectionR01AI114625 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2015 to 2019
$1.9MNutritional immunity during Salmonella infectionR37AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Manuela Raffatellu · 2023 to 2026
$1.8MNCCIH NIH HHS R01 AT007452NIAID NIH HHS R01 AI108917NIAID NIH HHS R01 AI114625NIAID NIH HHS R01 AI126277NIAID NIH HHS R01 AI144403NIAID NIH HHS R37 AI126277
Abstract
Impaired T cell immunity with aging increases mortality from infectious disease. The branching of Asparagine-linked glycans is a critical negative regulator of T cell immunity. Here we show that branching increases with age in females more than males, in naïve more than memory T cells, and in CD4
Indexed as
AcetylglucosamineCD8-Positive T-LymphocytesAgingAnimalsFemaleHumansInterleukin-7MaleMicePolysaccharidesAcetylglucosamineInterleukin-7PolysaccharidesagingimmunityImmunosenescenceinterleukin-7N-acetyglucosamineN-glycan branchingN-glycosylationT cell, infection
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