Evidence map›Paper›PMID 35528477›Full record

ArticleJournal of traditional and complementary medicine2022

Daniele Corrêa Fernandes, Bruna Paiva Martins, Girlaine Pereira da Silva, Eduardo Nunes da Fonseca, Shirley Vânia Moura Santos, Leosvaldo Salazar Marques Velozo, Carlos Roberto Machado Gayer, Kátia Costa de Carvalho Sabino, Marsen Garcia Pinto Coelho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniele Corrêa FernandesDepartment of Biochemistry and Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Bruna Paiva MartinsDepartment of Biochemistry and Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Girlaine Pereira da SilvaDepartment of Biochemistry and Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Eduardo Nunes da FonsecaDepartment of Plant Biology, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Shirley Vânia Moura SantosDepartment of Biochemistry and Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Leosvaldo Salazar Marques VelozoDepartment of Biochemistry and Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Carlos Roberto Machado GayerDepartment of Biochemistry and Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Kátia Costa de Carvalho SabinoDepartment of Biochemistry and Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Marsen Garcia Pinto CoelhoDepartment of Biochemistry and Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimEXPERIMENTAL PROCEDURE: The antinociceptive activity was determined by acetic acid-induced writhing, formalin test, tail immersion test, hot-plate test, xylene-induced ear edema methods, and the evaluation of its mechanism was performed in the writhing model. The aqueous extract of RESULTS AND

conclusionFr20 (all doses) and Fr40 (100 mg/kg) reduced the nociception in the tail-flick model. Both fractions increased the percentage of maximum possible effect with 25 mg/kg, in the hot-plate assay, at 60 min, while AEEm reduced pain only with 50 and 100 mg/kg. There was a reduction in xylene-edema index, with Fr40 (25 mg/kg), AEEm (50 mg/kg) and Fr20 (50 mg/kg). All doses of AEEm, Fr20, and Fr40 reduced both phases of the formalin model. In the abdominal contortion model, Fr40 presented the highest activity, reducing 96% of contortions and its antinociceptive mechanism was evaluated. The results indicated the involvement of NO and adrenergic activation pathways. The main components of Fr40 are swertisin, swertiajaponin, isoorientin 7,3'-dimethyl ether, swertisin-O-rhamnoside, isoorientin, isovitexin, isovitexin-Orhamnoside, and isovitexin-7-O-glucoside. The aqueous extract of

Indexed as

7-NI, 7-nitroindazoleAdrenergic pathwayAEEm, aqueous extract of E. macrophyllusChemicalDAD-UV diode array detector, ultravioletESI-MS, electrospray ionization mass spectrometerFlavonoid derivativesFr20, fraction isolated from EAEm on Sephadex LH-20 with 20% ethanolFr40, fraction isolated from EAEm on Sephadex LH-20 with 40% ethanolGMPc, cyclic guanosine monophosphateHPLC, high-performance liquid chromatographyHPTLC, high-performance thin-layer chromatographyMedicinal plantsMPE, percentage of the maximum possible effectNO, nitric oxideNO pathwayNP/PEG, natural products reagent/polyethylene glycol.NSAIDs, nonsteroidal anti-inflammatory drugsODQ, 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-oneQ-TOF, quadrupole time-of-flightThermal and neurogenic assays

Identifiers

PMID35528477
PMCPMC9072821

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.