Evidence map›Paper›PMID 35528091›Full record

ArticleRSC advances2019

Bulky cations greatly increase the turnover of a native hammerhead ribozyme.

Shu-Ichi Nakano, Hirofumi Yamashita, Kazuya Tanabe, Naoki Sugimoto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Shu-Ichi NakanoDepartment of Nanobiochemistry, Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University 7-1-20, Minatojima-minamimachi, Chuo-ku Kobe 650-0047 Japan shuichi@konan-u.ac.jp.ORCID https://orcid.org/0000-0001-9415-7014
Hirofumi YamashitaDepartment of Nanobiochemistry, Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University 7-1-20, Minatojima-minamimachi, Chuo-ku Kobe 650-0047 Japan shuichi@konan-u.ac.jp.
Kazuya TanabeDepartment of Nanobiochemistry, Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University 7-1-20, Minatojima-minamimachi, Chuo-ku Kobe 650-0047 Japan shuichi@konan-u.ac.jp.
Naoki SugimotoDepartment of Nanobiochemistry, Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University 7-1-20, Minatojima-minamimachi, Chuo-ku Kobe 650-0047 Japan shuichi@konan-u.ac.jp.
Konan University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods to facilitate the catalytic turnover of ribozymes are required for advancing oligonucleotide-based technologies. This study examined tetraalkylammonium ions for their ability to increase the efficiency of catalytic turnover of a native hammerhead ribozyme. Kinetic analysis showed that large tetraalkylammonium ions significantly increased the turnover rate of the ribozyme and was much more effective than poly(ethylene glycol) (PEG) and urea. The magnitude of the rate increase depended on the concentrations of Mg

Identifiers

PMID35528091
PMCPMC9074697
OpenAlexW2985186291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.