Evidence map›Paper›PMID 35528069›Full record

ReviewRSC advances2019

Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview.

Subhankar Mukhopadhyay, Hanitrarimalala Veroniaina, Tadious Chimombe, Lidong Han, Wu Zhenghong, Qi Xiaole

Open access · goldAbstract readReview
In one paragraph

Review in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Effect of Non-Modified as Well as Surface-Modified SiOInternational journal of molecular sciences · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Subhankar MukhopadhyayKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University Nanjing 210009 PR China zhenghongwu66@cpu.edu.cn qixiaole523@cpu.edu.cn +86-025-83179703 +86-15062208341.
Hanitrarimalala VeroniainaKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University Nanjing 210009 PR China zhenghongwu66@cpu.edu.cn qixiaole523@cpu.edu.cn +86-025-83179703 +86-15062208341.
Tadious ChimombeKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University Nanjing 210009 PR China zhenghongwu66@cpu.edu.cn qixiaole523@cpu.edu.cn +86-025-83179703 +86-15062208341.
Lidong HanKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University Nanjing 210009 PR China zhenghongwu66@cpu.edu.cn qixiaole523@cpu.edu.cn +86-025-83179703 +86-15062208341.
Wu ZhenghongKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University Nanjing 210009 PR China zhenghongwu66@cpu.edu.cn qixiaole523@cpu.edu.cn +86-025-83179703 +86-15062208341.ORCID https://orcid.org/0000-0002-0244-329X
Qi XiaoleKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University Nanjing 210009 PR China zhenghongwu66@cpu.edu.cn qixiaole523@cpu.edu.cn +86-025-83179703 +86-15062208341.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protean mesoporous silica nanoparticles (MSNs) are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including (but not limited to) changeable pore size, mesoporosity, high drug loading capacity, and biodegradability. MSNs have been drawing considerable attention as competent, safer and effective drug delivery vehicles day by day by their towering mechanical, chemical and thermal characteristics. Straightforward and easy steps are involved in the synthesis of MSNs at a relatively cheaper cost. This review reports Stober's synthesis, the first proposed synthesis procedure to prepare micron-sized, spherical MSNs, followed by other modifications later on done by scientists. To ensure the safety and compatibility of MSNs with biological systems, the hemocompatibility evaluation of MSNs using human red blood cells (RBCs) is a widely welcomed exercise. Though our main vision of this overview is to emphasize more on the hemocompatibility of MSNs to RBCs, we also brief about the synthesis and widespread applications of multifaceted MSNs. The strike of different parameters of MSNs plays a crucial role concerning the hemolytic activity of MSNs, which also has been discussed here. The inference is derived by centering some feasible measures that can be adopted to cut down or stop the hemolytic activity of MSNs in the future.

Identifiers

PMID35528069
PMCPMC9074774
OpenAlexW2987207784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.