Evidence map›Paper›PMID 35528066›Full record

ArticleRSC advances2019

Discovery of dihydrooxazolo[2,3-

Lixia Ding, Lu Wang, Kun Zou, Bo Li, Yunqing Song, Qihua Zhang, Yitian Zhao, Zhijian Xu, Guangbo Ge, Bo Zhao and 1 more

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Rapalogues as hCES2A Inhibitors: In Vitro and In Silico Investigations.European journal of drug metabolism and pharmacokinetics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lixia DingKey Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China boli@simm.ac.cn wlzhu@simm.ac.cn.
Lu WangShanghai University of Traditional Chinese Medicine 1200 Cailun Road Shanghai 201203 China geguangbo@dicp.ac.cn.
Kun ZouKey Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China boli@simm.ac.cn wlzhu@simm.ac.cn.
Bo LiKey Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China boli@simm.ac.cn wlzhu@simm.ac.cn.ORCID https://orcid.org/0000-0002-4279-4596
Yunqing SongShanghai University of Traditional Chinese Medicine 1200 Cailun Road Shanghai 201203 China geguangbo@dicp.ac.cn.
Qihua ZhangKey Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China boli@simm.ac.cn wlzhu@simm.ac.cn.
Yitian ZhaoShanghai University of Traditional Chinese Medicine 1200 Cailun Road Shanghai 201203 China geguangbo@dicp.ac.cn.
Zhijian XuKey Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China boli@simm.ac.cn wlzhu@simm.ac.cn.ORCID https://orcid.org/0000-0002-3063-8473
Guangbo GeShanghai University of Traditional Chinese Medicine 1200 Cailun Road Shanghai 201203 China geguangbo@dicp.ac.cn.
Bo ZhaoCollege of Chemistry and Materials Science, Nanjing Normal University 1 Wenyuan Road Nanjing 210097 China zhaobo@njnu.edu.cn.
Weiliang ZhuKey Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 China boli@simm.ac.cn wlzhu@simm.ac.cn.ORCID https://orcid.org/0000-0001-6699-5299
Chinese Academy of Sciences · CNShanghai University of Traditional Chinese Medicine · CNNanjing Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human carboxylesterase 2 (hCE2) is one of the most abundant esterases distributed in human small intestine and colon, which participates in the hydrolysis of a variety of ester-bearing drugs and thereby affects the efficacy of these drugs. Herein, a new compound (23o) with a novel skeleton of dihydrooxazolo[2,3-

Identifiers

PMID35528066
PMCPMC9074662
OpenAlexW2983432576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.