Evidence map›Paper›PMID 35528064›Full record

ArticleRSC advances2019

Regulation of the pyruvate metabolism node by monogene and polygene engineering of HEK-293 cells.

Li Xie, Junqing Miao, Xiangchao Li, Xiaoping Yi, Ju Chu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Li XieState Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology 130 Mei Long Road, Xu Hui District Shanghai 200237 China xpyi@ecust.edu.cn +86 21 64253337.ORCID https://orcid.org/0000-0002-0708-0360
Junqing MiaoState Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology 130 Mei Long Road, Xu Hui District Shanghai 200237 China xpyi@ecust.edu.cn +86 21 64253337.
Xiangchao LiState Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology 130 Mei Long Road, Xu Hui District Shanghai 200237 China xpyi@ecust.edu.cn +86 21 64253337.
Xiaoping YiState Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology 130 Mei Long Road, Xu Hui District Shanghai 200237 China xpyi@ecust.edu.cn +86 21 64253337.
Ju ChuState Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology 130 Mei Long Road, Xu Hui District Shanghai 200237 China xpyi@ecust.edu.cn +86 21 64253337.
East China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HEK-293 cells are increasingly being used in the production of human adenovirus (HAdV) vaccines. However, the production of HAdV vaccine has not met the requirements of industrial production. Recently, we investigated the effects of various regulatory genes of the pyruvate metabolism node on the substance and energy metabolism and adenovirus reproduction in HEK-293 cells. Initially, single regulatory genes, including

Identifiers

PMID35528064
PMCPMC9074685
OpenAlexW2985372938

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.