ArticleFrontiers in endocrinology2022
Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Mendelian randomization studies on coronary artery disease: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies.Journal of the American Heart Association · 2023Pooled it
- Association Between Fasting Blood Glucose and Myocardial Infarction Risk: Findings From the 2015-2018 NHANES Database and Mendelian Randomization Studies.Cardiology research and practice · 2026Article
- Advances in Molecular Mechanisms and Precision Interventions of Cardiovascular Injuries Related to Glucose and Lipid Metabolism Disorders.Reviews in cardiovascular medicine · 2025Review
- Diabetes, glycaemic traits and cardiovascular disease in females and males: Observational and Mendelian randomisation analyses in the UK Biobank.Diabetes, obesity & metabolism · 2025Observational
- Correlations between lipid profiles and atherosclerotic plaque characteristics in adult patients with type 2 diabetes mellitus.Frontiers in clinical diabetes and healthcare · 2025Article
- The causal relationship between 5 serum lipid parameters and diabetic nephropathy: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Association between high-density lipoprotein cholesterol and type 2 diabetes mellitus: dual evidence from NHANES database and Mendelian randomization analysis.Frontiers in endocrinology · 2024Article
- The causal relationship between human brain morphometry and knee osteoarthritis: a two-sample Mendelian randomization study.Frontiers in genetics · 2024Article
- Elucidation of genetic determinants of dyslipidaemia using a global screening array for the early detection of coronary artery disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- Type 2 Diabetes and Atrial Fibrillation: Evaluating Causal and Pleiotropic Pathways Using Mendelian Randomization.Journal of the American Heart Association · 2023Article
- Causal associations between type 1 diabetes mellitus and cardiovascular diseases: a Mendelian randomization study.Cardiovascular diabetology · 2023Article
- Associations between body composition profile and hypertension in different fatty liver phenotypes.Frontiers in endocrinology · 2023Article
- Advancing a causal role of type 2 diabetes and its components in developing macro- and microvascular complications via genetic studies.Diabetic medicine : a journal of the British Diabetic Association · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: We aimed to evaluate the causal effect of type 2 diabetes mellitus (T2DM) and glycemic traits on the risk of a wide range of cardiovascular diseases (CVDs) and lipid traits using Mendelian randomization (MR). Methods: Genetic variants associated with T2DM, fasting glucose, fasting insulin, and hemoglobin A1c were selected as instrumental variables to perform both univariable and multivariable MR analyses. Results: In univariable MR, genetically predicted T2DM was associated with higher odds of peripheral artery disease (pooled odds ratio (OR) =1.207, 95% CI: 1.162-1.254), myocardial infarction (OR =1.132, 95% CI: 1.104-1.160), ischemic heart disease (OR =1.129, 95% CI: 1.105-1.154), heart failure (OR =1.050, 95% CI: 1.029-1.072), stroke (OR =1.087, 95% CI: 1.068-1.107), ischemic stroke (OR =1.080, 95% CI: 1.059-1.102), essential hypertension (OR =1.013, 95% CI: 1.010-1.015), coronary atherosclerosis (OR =1.005, 95% CI: 1.004-1.007), and major coronary heart disease event (OR =1.003, 95% CI: 1.002-1.004). Additionally, T2DM was causally related to lower levels of high-density lipoprotein cholesterol (OR =0.965, 95% CI: 0.958-0.973) and apolipoprotein A (OR =0.982, 95% CI: 0.977-0.987) but a higher level of triglycerides (OR =1.060, 95% CI: 1.036-1.084). Moreover, causal effect of glycemic traits on CVDs and lipid traits were also observed. Finally, most results of univariable MR were supported by multivariable MR. Conclusion: We provided evidence for the causal effects of T2DM and glycemic traits on the risk of CVDs and dyslipidemia. Further investigations to elucidate the underlying mechanisms are warranted.
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