ArticleFrontiers in aging neuroscience2022
Associations Between Age and Resting State Connectivity Are Partially Dependent Upon Cardiovascular Fitness.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Cardiorespiratory fitness is differentially associated with motor cortex laterality in middle-aged and older adults.Scientific reports · 2026Article
- The effort hypothesis at the heart of the virtuous circle.EXCLI journal · 2025Review
- Temperament & Character account for brain functional connectivity at rest: A diathesis-stress model of functional dysregulation in psychosis.Molecular psychiatry · 2023Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
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Abstract
Previous research suggests a marked impact of aging on structural and functional connectivity within the frontoparietal control network (FPCN) and default mode network (DMN). As aging is also associated with reductions in cardiovascular fitness, age-related network connectivity differences reported by past studies could be partially due to age-related declines in fitness. Here, we use data collected as part of a 16-week exercise intervention to explore relationships between fitness and functional connectivity. Young and older adults completed baseline assessments including cardiovascular fitness, health and functioning measures, and an fMRI session. Scan data were acquired on a Siemens 3T MRI scanner with a 32-channel head coil. Results from regression analyses indicated that average connectivity did not differ between young and older adults. However, individual ROI-to-ROI connectivity analyses indicated weaker functional correlations for older adults between specific regions in the FPCN and DMN and, critically, many of these differences were attenuated when fitness was accounted for. Taken together, findings suggest that fitness exerts regional rather than global effects on network connectivity.
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Registered trials
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