Evidence map›Paper›PMID 35527491›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Construction and identification of a HEK293 cell line with stable TrxR1 overexpression].

X Lü, Z Zhou, L Zhu, J Zhou, H Huang, C Zhang, X Liu

Open access · greenAbstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

X LüCenter of Drug Screening and Evaluation, Wannan Medical College, Wuhu 241000, China.
Z ZhouCenter of Drug Screening and Evaluation, Wannan Medical College, Wuhu 241000, China.
L ZhuCenter of Drug Screening and Evaluation, Wannan Medical College, Wuhu 241000, China.
J ZhouCenter for Reproductive Medicine, First Affiliated Hospital of Wannan Medical College, Wuhu 241000, China.
H HuangCenter of Drug Screening and Evaluation, Wannan Medical College, Wuhu 241000, China.
C ZhangCenter of Drug Screening and Evaluation, Wannan Medical College, Wuhu 241000, China.
X LiuCenter of Drug Screening and Evaluation, Wannan Medical College, Wuhu 241000, China.
Wannan Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo construct a HEK293 cell line stably overexpressing TrxR1 as a cell model for functional study of TrxR1 and screening of TrxR1-targeting drugs.

methods

results

conclusionWe successfully obtained a HEK293 cell line with stable TrxR1 overexpression, which shows resistance to auranofin and can be used for screening TrxR1 targeting drugs.

Indexed as

AuranofinLentivirusCell Line, TumorGenetic VectorsHEK293 CellsHumansRNA, MessengerTransfectionAuranofinRNA, Messengercell modellentiviral packagingoverexpressionthioredoxin reductase 1

Identifiers

PMID35527491
PMCPMC9085581
OpenAlexW4229453117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.