Evidence map›Paper›PMID 35527311›Full record

ArticleJournal of neurovirology2022

T-lymphocyte activation markers in patients with HIV-1-associated neurocognitive disorder.

Claudete M S Ferreira, Noemia M O Sunada, Jorge Casseb

Abstract read
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In one paragraph

Article in Journal of neurovirology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Claudete M S FerreiraLaboratory of Medical Investigation LIM 56, Division of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.
Noemia M O SunadaLaboratory of Medical Investigation LIM 56, Division of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.
Jorge CassebLaboratory of Medical Investigation LIM 56, Division of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil. jcasseb@usp.br.ORCID 0000-0002-4553-2559
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite immune-reconstitution, after TARc HIV-positive patients, neurocognitive disorders related to HIV-1 (HAND) have been observed in these patients. The diagnosis occurs, in most cases, in the advanced stage. The objective of this study is to quantify activation markers (CD25, CD38, CD69, and HLA-DR) in the blood of patients with chronic HIV-1 infection and relate to HAND and premature senescence. The level of activation markers was quantified in the blood of 10 HIV-positive patients with HAND, 10 cases without HAND undergoing regular follow-up at the Secondary Immunodeficiency Clinic (ADEE3002) at the Hospital of Clinics of the Medical School of São Paulo, and 10 healthy seronegative volunteers using the flow cytometry method. Subsequently, the analysis was performed using the FlowJo™ v10.6.1 program and GraphPad Prism 8.3.0. In addition to T CD4

Indexed as

HIV-1HIV InfectionsHIV SeropositivityBrazilCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFlow CytometryHLA-DR AntigensHumansLeukocyte Common AntigensLeukocytes, MononuclearLymphocyte ActivationNeurocognitive DisordersHLA-DR AntigensLeukocyte Common AntigensBloodHANDMarkersSenescence

Identifiers

PMID35527311
OpenAlexW4229332793

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.