Evidence map›Paper›PMID 35527262›Full record

ReviewTranslational neurodegeneration2022

A new paradigm for diagnosis of neurodegenerative diseases: peripheral exosomes of brain origin.

Neelam Younas, Leticia Camila Fernandez Flores, Franziska Hopfner, Günter U Höglinger, Inga Zerr

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational neurodegeneration, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Astrocytes promote oligodendrocyte precursor cell proliferation via Cx47Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Neelam YounasPrion Research Group, Department of Neurology, National Reference Center for Surveillance of TSE, Universitätsklinikum Göttingen: Universitätsmedizin Göttingen, Georg-August University, Göttingen, Germany, Robert-Koch-Strasse 40, 37075, Göttingen, Germany. neelam.younas@med.uni-goettingen.de.ORCID http://orcid.org/0000-0003-0421-5247
Leticia Camila Fernandez FloresPrion Research Group, Department of Neurology, National Reference Center for Surveillance of TSE, Universitätsklinikum Göttingen: Universitätsmedizin Göttingen, Georg-August University, Göttingen, Germany, Robert-Koch-Strasse 40, 37075, Göttingen, Germany.
Franziska HopfnerHannover Medical School, Medizinische Hochschule Hannover, Hannover, Germany.
Günter U HöglingerHannover Medical School, Medizinische Hochschule Hannover, Hannover, Germany.
Inga ZerrPrion Research Group, Department of Neurology, National Reference Center for Surveillance of TSE, Universitätsklinikum Göttingen: Universitätsmedizin Göttingen, Georg-August University, Göttingen, Germany, Robert-Koch-Strasse 40, 37075, Göttingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases are a heterogeneous group of maladies, characterized by progressive loss of neurons. These diseases involve an intricate pattern of cross-talk between different types of cells to maintain specific signaling pathways. A component of such intercellular cross-talk is the exchange of various types of extracellular vesicles (EVs). Exosomes are a subset of EVs, which are increasingly being known for the role they play in the pathogenesis and progression of neurodegenerative diseases, e.g., synucleinopathies and tauopathies. The ability of the central nervous system exosomes to cross the blood-brain barrier into blood has generated enthusiasm in their study as potential biomarkers. However, the lack of standardized, efficient, and ultra-sensitive methods for the isolation and detection of brain-derived exosomes has hampered the development of effective biomarkers. Exosomes mirror heterogeneous biological changes that occur during the progression of these incurable illnesses, potentially offering a more comprehensive outlook of neurodegenerative disease diagnosis, progression and treatment. In this review, we aim to discuss the challenges and opportunities of peripheral biofluid-based brain-exosomes in the diagnosis and biomarker discovery of Alzheimer's and Parkinson's diseases. In the later part, we discuss the traditional and emerging methods used for the isolation of exosomes and compare their advantages and disadvantages in clinical settings.

Indexed as

ExosomesExtracellular VesiclesNeurodegenerative DiseasesBiomarkersBrainHumansBiomarkersAlzheimer’s diseaseBlood–brain barrierCentral nervous systemDiagnosisExosomesParkinson’s disease

Identifiers

PMID35527262
PMCPMC9082915

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.