Evidence map›Paper›PMID 35527261›Full record

ArticleAdvances in rheumatology (London, England)2022

Reference range of serum uric acid and prevalence of hyperuricemia: a cross-sectional study from baseline data of ELSA-Brasil cohort.

Murillo Dório, Isabela M Benseñor, Paulo Lotufo, Itamar S Santos, Ricardo Fuller

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Article in Advances in rheumatology (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Murillo DórioDivision of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Avenida Doutor Arnaldo 455, 3 andar sala 3131, Cerqueira César, São Paulo, CEP: 01246-903, Brazil. murillodorio@gmail.com.ORCID 0000-0002-1732-9123
Isabela M BenseñorCenter for Clinical and Epidemiological Research, Hospital Universitario, University of Sao Paulo, São Paulo, Brazil.
Paulo LotufoCenter for Clinical and Epidemiological Research, Hospital Universitario, University of Sao Paulo, São Paulo, Brazil.
Itamar S SantosCenter for Clinical and Epidemiological Research, Hospital Universitario, University of Sao Paulo, São Paulo, Brazil.
Ricardo FullerDivision of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Avenida Doutor Arnaldo 455, 3 andar sala 3131, Cerqueira César, São Paulo, CEP: 01246-903, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost of the few studies that have established reference ranges for serum uric acid (SUA) have not taken into account factors which may interfere with its levels and followed rigorous laboratory quality standards. The aim of this study was to establish reference ranges for SUA and determine the prevalence of hyperuricemia.

methodCross-sectional study including 15,100 participants (all sample) aged 35 to 74 years from baseline data of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a multicentric cohort of volunteer civil servants from five universities and one research institute located in different regions of Brazil. It was established a reference sample excluding participants with factors that directly influence SUA levels: glomerular filtration rate lower than 60 ml/min, excessive alcohol intake, use of diuretics, aspirin, estrogen or urate-lowering therapy. SUA was measured using the uricase method and following rigorous international quality standards. Reference ranges were defined as values between percentiles 2.5 (P2.5) and 97.5 (P97.5) of SUA distribution in the reference sample, stratified by sex. Hyperuricemia was defined as SUA ≥ 7 mg/100 ml in the all sample.

resultsThe reference sample was composed of 10,340 individuals (55.3% women, median age 50 years). Reference ranges (P2.5 to P97.5) for SUA were: 4.0 to 9.2 mg/100 ml for men and 2.8 to 6.9 mg/100 ml for women. Sex was a major determinant for SUA levels (median [IQR], mg/100 ml: 6.1 [5.3-7.0] for men versus 4.5 [3.9-5.3] for women, p < 0.001). Higher levels of SUA were found in patients with higher BMI. Higher age had (a modest) influence only for women. The prevalence of hyperuricemia for all sample (N = 15,100) was 31.9% (95% confidence interval [CI] 30.8-33.0%) in men and 4.8% (95% CI 4.3-5.3%) in women.

conclusionSUA reference ranges were 4.0 to 9.2 mg/100 ml for men and 2.8 to 6.9 mg/100 ml for women. Prevalence of hyperuricemia was 31.9% in men and 4.8% in women. Updated SUA reference ranges and prevalence of hyperuricemia are higher nowadays and might be used to guide laboratories and the screening for diseases related to SUA.

Indexed as

HyperuricemiaAdultBrazilCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedPrevalenceReference ValuesUric AcidUric AcidHyperuricemiaReference rangeSerum uric acid

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PMID35527261

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