Evidence map›Paper›PMID 35527242›Full record

ArticleBMC geriatrics2022

Associations between inflammation, coagulation, cardiac strain and injury, and subclinical vascular disease with frailty in older men: a cross-sectional study.

Douglas G J McKechnie, Meera Patel, A Olia Papacosta, Lucy T Lennon, Elizabeth A Ellins, Julian P J Halcox, Sheena E Ramsay, Peter H Whincup, S Goya Wannamethee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Article
  3. Observational
  4. Article
  5. High-sensitivity cardiac troponin I and frailty: associations with the frailty index and Fried phenotype in older women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
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  14. Role of Endothelial Progenitor Cells in Frailty.International journal of molecular sciences · 2023
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Douglas G J McKechnieDepartment of Primary Care and Population Health, University College London, London, NW3 2PF, UK. douglas.mckechnie.11@ucl.ac.uk.
Meera PatelDepartment of Primary Care and Population Health, University College London, London, NW3 2PF, UK.
A Olia PapacostaDepartment of Primary Care and Population Health, University College London, London, NW3 2PF, UK.
Lucy T LennonDepartment of Primary Care and Population Health, University College London, London, NW3 2PF, UK.
Elizabeth A EllinsInstitute of Life Science, Swansea University, Swansea, UK.
Julian P J HalcoxInstitute of Life Science, Swansea University, Swansea, UK.
Sheena E RamsayPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Peter H WhincupPopulation Health Research Institute, St George's University of London, London, UK.
S Goya WannametheeDepartment of Primary Care and Population Health, University College London, London, NW3 2PF, UK.
University College London · GBSwansea University · GBNewcastle University · GBSt George's, University of London · GB

Funding

British Heart Foundation PG/09/024/26857British Heart Foundation RG/13/16/30528British Heart Foundation RG/19/4/34452Department of HealthMedical Research Council MR/K02325X/1
6 · The paper itself

Abstract

backgroundInflammation, coagulation activation, endothelial dysfunction and subclinical vascular disease are cross-sectionally associated with frailty. Cardiac-specific biomarkers are less-well characterised. We assessed associations between these and frailty, in men with, and without, cardiovascular disease (CVD).

methodsCross-sectional analysis of 1096 men without, and 303 with, CVD, aged 71-92, from the British Regional Heart Study. Multinominal logistic regression was performed to examine the associations between frailty status (robust/pre-frail/frail) and, separately, C-reactive protein (CRP), interleukin-6 (IL-6), tissue plasminogen activator (tPA), D-dimer, von Willebrand factor (vWF), high-sensitivity cardiac troponin-T (hs-cTnT), N-terminal pro B-type natriuretic peptide (NT-proBNP) (all natural log-transformed), and, in men without CVD, carotid intima-media thickness (CIMT), carotid-femoral pulse wave velocity (cfPWV), carotid distensibility coefficient (DC), and ankle-brachial pressure index (ABPI), adjusted for age, renal function, BMI, social class, smoking, polypharmacy, cognition, multimorbidity and systolic blood pressure. Explanatory variables with p < 0.05 were carried forward into mutually-adjusted analysis.

resultsIn men without CVD, higher CRP, IL-6, vWF, tPA, hs-cTnT, NT-proBNP, cfPWV, and lower DC were significantly associated with frailty; mutually-adjusted, log IL-6 (OR for frailty = 2.02, 95%CI 1.38-2.95), log hs-cTnT (OR = 1.95, 95%CI 1.24-3.05) and DC (OR = 0.92, 95%CI 0.86-0.99) retained associations. In men with CVD, higher CRP, IL-6, and hs-cTnT, but not vWF, tPA, NT-proBNP or D-dimer, were significantly associated with frailty; mutually-adjusted, log hs-cTnT (OR 3.82, 95%CI 1.84-7.95) retained a significant association.

conclusionsIn older men, biomarkers of myocardial injury are associated with frailty. Inflammation is associated with frailty in men without CVD. Carotid artery stiffness is associated with frailty in men without CVD, independently of these biomarkers.

Indexed as

Cardiovascular DiseasesFrailtyVascular DiseasesAgedAged, 80 and overBiomarkersCarotid Intima-Media ThicknessCross-Sectional StudiesHumansInflammationInterleukin-6MaleNatriuretic Peptide, BrainPeptide FragmentsPulse Wave AnalysisRisk FactorsBiomarkersInterleukin-6Natriuretic Peptide, BrainPeptide FragmentsTissue Plasminogen ActivatorTroponin Tvon Willebrand FactorAgingAtherosclerosisBiomarkersCardiovascular diseasesFrailty

Identifiers

PMID35527242
PMCPMC9082861
OpenAlexW4229369364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.