Evidence map›Paper›PMID 35527126›Full record

Trial reportNutrition, metabolism, and cardiovascular diseases : NMCD2022

Effect of physical activity in a weight loss program on circulating total ANGPTL8 concentrations in northern Americans with obesity: A prospective randomized controlled trial.

Chia-Po Fu, Elizabeth E Oczypok, Hira Ali, James P DeLany, Valerie L Reeves, Ruey-Feng Chang, Erin E Kershaw

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Chia-Po FuGraduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Elizabeth E OczypokDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Hira AliDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
James P DeLanyTranslational Research Institute Adventhealth, Florida, USA.
Valerie L ReevesCustomer Delivery, Data Science Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02412, USA.
Ruey-Feng ChangGraduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan.
Erin E KershawDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: kershawee@upmc.edu.
University of Pittsburgh · USNational Taiwan University · TWBroad Institute · USTranslational Research Institute for Metabolism and Diabetes · US

Funding

T32 Research Training in Diabetes and EndocrinologyT32DK007052 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBERT M O'DOHERTY · 1986 to 2026
$6.3M
NIDDK NIH HHS T32 DK007052
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe primary goals of this study were to clarify 1) the effect of weight loss by lifestyle intervention on circulating total angiopoietin-like protein 8 (ANGPTL8), and 2) the role of physical activity on serum total ANGPTL8 in northern Americans with obesity but without diabetes. METHODS AND

resultsA total of 130 subjects with body mass index (BMI) ≧ 35 kg/m

conclusionAmong northern Americans with obesity but without diabetes, a lifestyle modification resulted in significant reduction of circulating total ANGPTL8 concentrations in a 6-month weight-loss period. Although addition of physical activity resulted in greater total and liver fat loss, it did not promote further significant decline of serum total ANGPTL8 beyond diet alone.

Indexed as

Peptide HormonesWeight Reduction ProgramsAngiopoietin-Like Protein 8Angiopoietin-like ProteinsBody Mass IndexExerciseHumansObesityProspective StudiesWeight LossAngiopoietin-Like Protein 8Angiopoietin-like ProteinsANGPTL8 protein, humanPeptide HormonesANGPTL8Physical activityWeight loss

Identifiers

PMID35527126
PMCPMC9233128
OpenAlexW4223501537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.