ArticleJournal of lipid research2022
Neuronal growth regulator 1 promotes adipocyte lipid trafficking via interaction with CD36.
Article in Journal of lipid research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Sex-specific changes in the hippocampal proteome of Negr1Biology of sex differences · 2026Article
- Unlocking Ethiopia's genomic landscape and its global significance: a call for inclusive genomics research.Human genomics · 2026Review
- Integrative single-cell analysis of metabolic syndrome reveals novel cellular heterogeneity and differentiation dynamics in adipose tissue.Diabetology & metabolic syndrome · 2025Article
- Article
- Peripheral gene dysregulation in Negr1-deficient mice: insights into possible links with affective behavior.Frontiers in molecular neuroscience · 2025Article
- VPS28 regulates triglyceride synthesis via ubiquitination in bovine mammary epithelial cells.Scientific reports · 2024Article
- Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain.Plastic and reconstructive surgery. Global open · 2024Article
- Optimized cell type signatures revealed from single-cell data by combining principal feature analysis, mutual information, and machine learning.Computational and structural biotechnology journal · 2023Article
- Neuronal growth regulator 1 may modulate interleukin-6 signaling in adipocytes.Frontiers in molecular biosciences · 2023Article
- IgLON4 Regulates Myogenesis via Promoting Cell Adhesion and Maintaining Myotube Orientation.Cells · 2022Article
- Six genetically linked mutations in the CD36 gene significantly delay the onset of Alzheimer's disease.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal growth regulator 1 (NEGR1) is a glycosylphosphatidylinositol-anchored membrane protein associated with several human pathologies, including obesity, depression, and autism. Recently, significantly enlarged white adipose tissue, hepatic lipid accumulation, and decreased muscle capacity were reported in Negr1-deficient mice. However, the mechanism behind these phenotypes was not clear. In the present study, we found NEGR1 to interact with cluster of differentiation 36 (CD36), the major fatty acid translocase in the plasma membrane. Binding assays with a soluble form of NEGR1 and in situ proximal ligation assays indicated that NEGR1-CD36 interaction occurs at the outer leaflet of the cell membrane. Furthermore, we show that NEGR1 overexpression induced CD36 protein destabilization in vitro. Both mRNA and protein levels of CD36 were significantly elevated in the white adipose tissue and liver tissues of Negr1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.