Evidence map›Paper›PMID 35526238›Full record

ArticleMagnetic resonance in medicine2022

Quantification of NAD

Martyna Dziadosz, Maike Hoefemann, André Döring, Malgorzata Marjańska, Edward John Auerbach, Roland Kreis

Abstract readComparative Study
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Development of aNature communications · 2024
    Trial
  2. Article
  3. Review
  4. Optimization ofMagnetic resonance in medicine · 2025
    Article
  5. Article
  6. Optimization ofmedRxiv : the preprint server for health sciences · 2024
    Article
  7. Article
  8. Downfield proton MRSI with whole-brain coverage at 3T.Magnetic resonance in medicine · 2023
    Article
  9. Identification of new resonances in downfieldMagnetic resonance in medicine · 2023
    Article
  10. Identification of l-Tryptophan by down-fieldMagnetic resonance in medicine · 2022
    Article
  11. Quantification of NADMagnetic resonance in medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martyna DziadoszMR Methodology, Department for Diagnostic and Interventional Neuroradiology & Department for Biomedical Research, University of Bern, Bern, Switzerland.
Maike HoefemannMR Methodology, Department for Diagnostic and Interventional Neuroradiology & Department for Biomedical Research, University of Bern, Bern, Switzerland.
André DöringCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK.
Malgorzata MarjańskaDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-4727-2447
Edward John AuerbachDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-4553-1545
Roland KreisMR Methodology, Department for Diagnostic and Interventional Neuroradiology & Department for Biomedical Research, University of Bern, Bern, Switzerland.ORCID 0000-0002-8618-6875

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger · 2019 to 2026
$11.7M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
NIBIB NIH HHS P41 EB027061NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

purposeThe detection of nicotinamide-adenine-dinucleotide (NAD

methodsA large brain volume in 10 healthy subjects was investigated with three techniques: semi-LASER with water-saturation (WS) (TE = 35 ms), semi-LASER with metabolite-cycling (MC) (TE = 35 ms), and the non-water-excitation (nWE) technique 2D ISIS-localization with chemical-shift-selective excitation (2D I-CSE) (TE = 10.2 ms). Spectra were quantified with optimized modeling in FiTAID.

resultsNAD

conclusionThree methods to assess NAD

Indexed as

BrainMagnetic Resonance SpectroscopyNADHealthy VolunteersHumansNADbraindetectabilityfittingmagnetization exchangemodelingMR spectroscopyNAD+precisionquantificationsaturation transfer

Identifiers

PMID35526238
PMCPMC9322547

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.