Evidence map›Paper›PMID 35526083›Full record

SynthesisEuropean eating disorders review : the journal of the Eating Disorders Association2022

A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.

Michelle Sader, Justin H G Williams, Gordon D Waiter

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in European eating disorders review : the journal of the Eating Disorders Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07098156 (Neuroanatomical Differences Associated With Anorexia Nervosa and Masking Behaviour in Autistic Individuals), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07098156 recruitingnot on this mapstarted 2025, after this paper: background citation

Neuroanatomical Differences Associated With Anorexia Nervosa and Masking Behaviour in Autistic Individuals

TypeobservationalSponsorUniversity of AberdeenRan2025 to 2026Enrolled50ConditionsAutism, Anorexia NervosaArmsSingle Research Visit 3T MRI Research Scan, Demographic and Behavioural Questionnaires
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michelle SaderTranslational Neuroscience, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Justin H G WilliamsTranslational Neuroscience, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Gordon D WaiterBiomedical Imaging Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
University of Aberdeen · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent research reports Anorexia Nervosa (AN) to be highly dependent upon neurobiological function. Some behaviours, particularly concerning food selectivity are found in populations with both Autism Spectrum Disorder (ASD) and AN, and there is a proportionally elevated number of anorexic patients exhibiting symptoms of ASD. We performed a systematic review of structural MRI literature with the aim of identifying common structural neural correlates common to both AN and ASD. Across 46 ASD publications, a meta-analysis of volumetric differences between ASD and healthy controls revealed no consistently affected brain regions. Meta-analysis of 23 AN publications revealed increased volume within the orbitofrontal cortex and medial temporal lobe, and adult-only AN literature revealed differences within the genu of the anterior cingulate cortex. The changes are consistent with alterations in flexible reward-related learning and episodic memory reported in neuropsychological studies. There was no structural overlap between ASD and AN. Findings suggest no consistent neuroanatomical abnormality associated with ASD, and evidence is lacking to suggest that reported behavioural similarities between those with AN and ASD are due to neuroanatomical structural similarities.

Indexed as

Anorexia NervosaAutism Spectrum DisorderAdultBrainCerebral CortexGray MatterHumansMagnetic Resonance Imaginganorexia nervosaautism spectrum disorderemotion awarenessmeta-analysisVBM

Identifiers

PMID35526083
PMCPMC9543727
OpenAlexW4229331710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.