SynthesisEuropean journal of medical research2022
Association of vitamin D receptor gene rs739837 polymorphism with type 2 diabetes and gestational diabetes mellitus susceptibility: a systematic review and meta-analysis.
Synthesis in European journal of medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- A plethora of laboratory protocols for vitamin D receptor (VDR) gene variants detection: a systematic review of associations with hypertensive disorders of pregnancy.BMC pregnancy and childbirth · 2025Pooled it
- Vitamin D Supplementation for the Outcomes of Patients with Gestational Diabetes Mellitus and Neonates: A Meta-Analysis and Systematic Review.International journal of clinical practice · 2023Pooled it
- Association betweenPeerJ · 2023Pooled it
- Association of VDR gene polymorphisms with prediabetes and Type 2 diabetes mellitus in a sample of the Iranian population.PloS one · 2026Article
- Association between vitamin D receptor FokI gene polymorphism and risk of type 2 diabetes mellitus in the Ethiopian population.Scientific reports · 2025Article
- Genetic association of vitamin D receptor polymorphisms (ApaI, BsmI, and FokI) with gestational diabetes mellitus in North Indian women: a case-control study.Diabetology & metabolic syndrome · 2025Article
- Effect of vitamin D supplementation on glycemic control, insulin sensitivity, and pregnancy outcomes in gestational diabetes patients undergoing dietary therapy.Journal of health, population, and nutrition · 2025Article
- Vitamin D binding protein and receptor prevalence in a large population with periodontitis: single nucleotide polymorphism and transcriptomic profiling.BMC oral health · 2024Article
- Association of VDR gene variant rs2228570-Heliyon · 2024Article
- The impact of vitamin D on the etiopathogenesis and the progression of type 1 and type 2 diabetes in children and adults.Frontiers in endocrinology · 2024Review
- Relationship between vitamin D deficiency and gestational diabetes: a narrative review.Frontiers in endocrinology · 2024Review
- Relevance of Serum Levels and Functional Genetic Variants in Vitamin D Receptor Gene among Saudi Women with Gestational Diabetes Mellitus.Nutrients · 2023Article
- Prevalence and risk factors for secondary hyperparathyroidism (SHPT) in patients undergoing bariatric surgery.Surgical endoscopy · 2023Article
- Association of miR-196a2 and miR-27a polymorphisms with gestational diabetes mellitus susceptibility in a Chinese population.Frontiers in endocrinology · 2023Article
- Modulatory Effects of Vitamin D: A Possible Approach to Mitigate Air Pollution Related Pregnancy Complications.Journal of reproduction & infertilityReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIncreasing evidence shows that genetic variants of genes in the diabetes mellitus (DM) metabolic pathway, such as the vitamin D receptor (VDR) gene rs739837 polymorphism, increase the risk of DM susceptibility. However, the findings have been inconsistent. The present study was performed to evaluate the association of VDR gene rs739837 and type 2 diabetes (T2DM) or gestational diabetes mellitus (GDM) risk.
methodsA comprehensive meta-analysis and a subgroup analysis were conducted to assess the association between VDR rs739837 and T2DM or GDM among five genetic models (dominant, recessive, homozygote heterozygote, and allele models) using a fixed or random model.
resultsThe meta-analysis included 9 studies. In the overall analysis, the results showed that VDR rs739837 was associated with an increased risk of T2DM or GDM in the allele model (T vs. G: OR = 1.088; 95% CI: 1.018-1.163; P = 0.012) and dominant model (TT + GT vs. GG: OR = 1.095; 95% CI: 1.001-1.197; P = 0.047). In the subgroup analysis, VDR rs739837 was also associated with an increased risk of T2DM in the allele model (T vs. G: OR = 1.159; 95% CI: 1.055-1.273; P = 0.002) and dominant model (TT + GT vs. GG: OR = 1.198; 95% CI: 1.048-1.370; P = 0.008). However, VDR rs739837 was not associated with GDM.
conclusionsSignificant associations were found between the VDR rs739837 polymorphism and T2DM susceptibility, but not with GDM.
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