ArticleNutrition & metabolism2022
Extracellular water to total body water ratio predicts survival in cancer patients with sarcopenia: a multi-center cohort study.
Article in Nutrition & metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 34 citations in OpenAlex.
- Age modifies the prognostic relevance of extracellular water-to-total body water ratio in rheumatoid arthritis: a retrospective cohort study.BMC rheumatology · 2026Article
- Relationship between body water distribution and sarcopenia in older adults: a systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Review
- Weight loss-independent associations of body composition changes with device-derived metabolic age during Mediterranean diet follow-up.Revista da Associacao Medica Brasileira (1992) · 2026Observational
- Elevated extracellular water to total body water ratio and low phase angle in relation to muscle function in middle-aged and older adults.Journal of the International Society of Sports Nutrition · 2025Article
- Effect on Reduction in Inflammatory Fluid and Improvement of Cell Membrane/Skeletal Muscle by Far-Infrared Rays Emitted from Loess Bio-Balls During Sleep.Biomedicines · 2025Article
- Non-linear association between extracellular water/total body water ratio and all-cause mortality: a population-based cohort study.Scientific reports · 2025Article
- Advancing Nutritional Care Through Bioelectrical Impedance Analysis in Critical Patients.Nutrients · 2025Review
- Novel bioparameters derived from bioimpedance measurements for accurate prediction of weight status in infant-juvenile individuals: A regression analysis.Journal of electrical bioimpedance · 2025Article
- Article
- Exploring Biomarkers for Excess Extracellular Fluid in the Context of Physical Function in Chronic Kidney Disease Patients.Journal of personalized medicine · 2024Article
- Effects of Far-Infrared Rays Emitted from Loess Bio-Balls on Lymphatic Circulation and Reduction of Inflammatory Fluids.Biomedicines · 2024Article
- Article
- Bioimpedance analysis for identifying new indicators of exercise-induced muscle damage.Scientific reports · 2024Article
- Association of bioimpedance analysis parameters trajectories with clinical outcomes in neurocritical patients.Heliyon · 2024Article
- Integrating classification and regression learners with bioimpedance methods for estimating weight status in infants and juveniles from the southern Cuba region.BMC pediatrics · 2024Article
- The role of various physiological and bioelectrical parameters for estimating the weight status in infants and juveniles cohort from the Southern Cuba region: a machine learning study.BMC pediatrics · 2024Article
- Edema Index Predicts Mortality in Patients with Chronic Heart Failure: A Prospective, Observational Study.Global heart · 2024Observational
- Postoperative complications in the pediatric population. Malnutrition or phase angle? Which one do we use?Frontiers in nutrition · 2024Article
- Article
- The Effect of Contrast Water Therapy on Dehydration during Endurance Training Camps in Moderate-Altitude Environments.Sports (Basel, Switzerland) · 2023Article
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundBody water measured by bioelectrical impedance analysis (BIA) predicts the outcomes of many diseases. This study aimed to evaluate the relationship between body water and the prognosis of cancer patients with sarcopenia.
methodsThis study employed 287 cancer patients with sarcopenia underwent BIA from a prospective multicenter study of patients with cancer in China from 2013 to 2020. The primary outcome of interest was all-cause mortality presented as the longest time to follow-up available. Eight indicators of body water [total body water, extracellular water, intracellular water, free fat mass, active cell mass, extracellular water/intracellular water, extracellular water/total body water (ECW/TBW), and intracellular water/total body water] were included in the research. Neutrophil-lymphocyte ratio (NLR) = neutrophil (× 10
resultsThe median age was 65 years old, and 138 (48%) patients were men. During a mean follow-up of 46 months, 140 deaths were recorded, resulting in a rate of 204.6 events per 1000 patient-years. ECW/TBW showed the best predictive accuracy (C-index = 0.619) compared to the other indicators [p = 0.004, adjusted HR (95% CI) 1.70 (1.18,2.44)]. In the middle tertile (0.385-0.405), ECW/TBW had a strong independent negative association with patient survival [adjusted HR (95% CI) 2.88 (1.39-5.97), p = 0.004]. Patients who had a high ECW/TBW (ECW/TBW ≥ 0.395) combined with a high NLR had 3.84-fold risk of mortality (p < 0.001, 95% CI 1.99,7.38).
conclusionsECW/TBW was better than other indicators in predicting survival of cancer patients with sarcopenia. High ECW/TBW combined with high NLR would further increase the risk of mortality.
trial registrationThe Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) (Chinese Clinical Trial Registry: ChiCTR1800020329, URL of registration: http://www.chictr.org.cn/showprojen.aspx?proj=31813 ).
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