Trial reportSubstance abuse treatment, prevention, and policy2022
Developing a novel treatment for patients with chronic pain and Opioid User Disorder.
Trial report in Substance abuse treatment, prevention, and policy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03363243 (Advancing STOP), which is not on this map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Advancing STOP: Self-regulation Therapy for Opioid Addiction and Pain
Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Study Protocol for a Pain Self-Management Intervention to Reduce Pain and Improve MOUD Engagement in Primary Care: A Randomized Trial.Substance use & addiction journal · 2026Trial
- The psychosocial pain management to improve opioid use disorder treatment outcomes study: Protocol for a randomized controlled trial.Contemporary clinical trials · 2025Article
- Article
- Pharmacological and behavioral pain treatment strategies for patients with opioid use disorder.Expert opinion on pharmacotherapy · 2025Review
- Integrating chronic pain management into care for patients with opioid use disorder.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Article
- Recent advances in the treatment of chronic pain and substance use disorders.Current opinion in psychology · 2025Review
- Psychological treatments for comorbid chronic pain and opioid use disorder: Current research and future directions.Current opinion in psychology · 2025Review
- Study Protocol for Pain Self-Management and Patient-Oriented Buprenorphine Dosing for Pain and Retention in Office-Based Opioid Treatment: A Hybrid Type 1, 2 × 2 Factorial Randomized Controlled Trial.Substance use & addiction journal · 2025Article
- Home care for patients with opioid use disorders: A qualitative study of registered nurses' experiences of pain management.Nursing open · 2024Article
- "I'm just searching to get better": Constructions of treatment citizenship on injectable opioid agonist treatment.Social science & medicine (1982) · 2024Article
- Inhibitory Effects of a Novel μ-Opioid Receptor Nonpeptide Antagonist, UD-030, on Morphine-Induced Conditioned Place Preference.International journal of molecular sciences · 2023Article
- Association between recent overdose and chronic pain among individuals in treatment for opioid use disorder.PloS one · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIt is critical to develop empirically based, community-treatment friendly, psychotherapy interventions to improve treatment for patients with comorbid chronic pain and Opioid Use Disorder. Understanding factors that increase patient adherence and attendance is important, along with strategies targeted to address those issues.
methodsBased on initial psychophysiology research on adults with OUD and chronic pain, we created an integrated cognitive-behavioral, 12-week outpatient group therapy called STOP (Self-regulation Therapy for Opioid addiction and Pain). In this study, we pilot tested STOP in a Stage 1a feasibility and acceptability study to identify unique treatment needs and factors that increased session attendance, adherence to treatment, and improved outcomes. Fourteen individuals on medication for OUD with co-occurring chronic pain participated.
resultsSTOP had high attendance rates (80%; and active patient engagement). Urine toxicology showed no illicit drug use after week 8. Data analysis from pre-intervention to a 3-month follow-up showed significant functional improvement (F(1,12) = 45.82;p < 0.001) and decreased pain severity levels (F(1,12) = 37.62;p < 0.01). Participants reported appreciation of the unique tools to counteract physiological activation during a pain flare or craving. Participants also reported benefit from in-session visual aids, applicable pain psychology information, take-home worksheets, tools for relaxation practice, learning to apply the therapy tools. DISCUSSION: STOP is a 90-min 12-week rolling-entry group therapy based on previous research identifying psychophysiological needs of pain and OUD patients that can be seamlessly incorporated into community addiction treatment clinics.
conclusionPreliminary results of STOP are promising with high patient engagement and adherence and significant reductions in drug use and pain.
trial registrationClinicalTrials.Gov NCT03363243 , Registered Dec 6, 2017.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.