Evidence map›Paper›PMID 35525877›Full record

SynthesisEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2023

The diagnostic and prognostic value of glial fibrillary acidic protein in traumatic brain injury: a systematic review and meta-analysis.

Yunlong Pei, Xiaojia Tang, Enpeng Zhang, Kongye Lu, Boming Xia, Jun Zhang, Yujia Huang, HengZhu Zhang, Lun Dong

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Traumatic brain injury: the research continues with higher data quality evolving!European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yunlong PeiDepartment of Clinical Medicine, Dalian Medical University, Dalian, Liaoning, China.
Xiaojia TangDepartment of Rehabilitation, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, China.
Enpeng ZhangDepartment of Clinical Medicine, Dalian Medical University, Dalian, Liaoning, China.
Kongye LuDepartment of Clinical Medicine, Dalian Medical University, Dalian, Liaoning, China.
Boming XiaDepartment of Emergency, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Jun ZhangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Yujia HuangDepartment of Neurosurgery, Clinical Medical College of Yangzhou University, No.98 Nantong Westroad, Yangzhou, 225001, Jiangsu, China.
HengZhu ZhangDepartment of Neurosurgery, Clinical Medical College of Yangzhou University, No.98 Nantong Westroad, Yangzhou, 225001, Jiangsu, China.
Lun DongDepartment of Neurosurgery, Clinical Medical College of Yangzhou University, No.98 Nantong Westroad, Yangzhou, 225001, Jiangsu, China. lundongu571@163.com.ORCID http://orcid.org/0000-0002-7372-331X

Funding

Hospital Level Support Projects Fcjs202050the Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research 201902
6 · The paper itself

Abstract

objectivesOver the years, blood biomarkers have been extensively applied for diagnostic and prognostic assessment of traumatic brain injury (TBI). Herein, we conducted a meta-analysis to evaluate the diagnostic and prognostic value of glial fibrillary acidic protein (GFAP) for TBI patients.

methodsThe online databases, including PubMed, Embase, Cochrane Library, CNKI, and WFSD, were systematically retrieved from inception until May 2021. The RevMan 5.3 software and Stata 15 were used to conduct data analysis.

resultsA total of 22 eligible studies comprising 3709 patients were included in this meta-analysis. The pooled results indicated that serum GFAP had a diagnostic value in detecting traumatic intracranial lesions (AUC 0.81; 95% CI 0.77-0.84; p < 0.00001). The pooled sensitivity and specificity were 0.93 (95% CI 0.81-0.98), and 0.66 (95% 0.53-0.77; p < 0.00001), respectively. For assessment of unfavorable outcome, the pooled sensitivity, specificity and AUC value were 0.66 (95% CI 0.54-0.76; p < 0.00001), 0.82(95% CI 0.72-0.90; p < 0.00001), and 0.82 (95% CI 0.76-0.88; p < 0.00001), respectively. Besides, GFAP exhibited a significant value in predicting mortality (AUC 0.81; 95% CI 0.77-0.84; p < 0.00001), with high sensitivity and specificity (0.86, 95% CI 0.79-0.92, p < 0.00001, and 0.66, 95% CI 0.52-0.77, p < 0.00001). The subgroup analysis indicated that the type of TBI and cut-off value were potential sources of heterogeneity, which influenced the pooled AUC values for mortality prediction.

conclusionsOur meta-analysis indicated that GFAP had diagnostic and prognostic value for TBI patients, especially during the early TBI.

Indexed as

Brain Injuries, TraumaticBiomarkersGlial Fibrillary Acidic ProteinHumansPrognosisSensitivity and SpecificityBiomarkersGlial Fibrillary Acidic ProteinDiagnosisGFAPMeta-analysisMortalityOutcomePrognosis

Identifiers

PMID35525877

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.