Evidence map›Paper›PMID 35525247›Full record

ArticleCell2022

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis.

Nathan E Reticker-Flynn, Weiruo Zhang, Julia A Belk, Pamela A Basto, Nichole K Escalante, Genay O W Pilarowski, Alborz Bejnood, Maria M Martins, Justin A Kenkel, Ian L Linde and 15 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 244 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
244citing papers in PubMed, 2 pooled it
28.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

244 citing papers in PubMed, 2 syntheses or guidelines pooled it, 358 citations in OpenAlex.

  1. Pooled it
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  12. Melanoma evolution in the lymph node shapes systemic outcomes.bioRxiv : the preprint server for biology · 2026
    Article
  13. Neutrophils in cancer.Nature reviews. Cancer · 2026
    Review
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184 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 2 institutions in 2 countries.

Nathan E Reticker-FlynnDepartment of Pathology, Stanford University, Stanford, CA 94305, USA. Electronic address: retickerflynn@stanford.edu.
Weiruo ZhangDepartment of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.
Julia A BelkDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Pamela A BastoDivision of Oncology, Department of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Nichole K EscalanteDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Genay O W PilarowskiDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Alborz BejnoodDepartment of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.
Maria M MartinsDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Justin A KenkelDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Ian L LindeDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Sreya BagchiDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Robert YuanDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Serena ChangInstitute for Immunity, Transplantation, and Infection Operations, Stanford University, Palo Alto, CA 94305, USA; Department of Otolaryngology-Head & Neck Surgery, Stanford University, Palo Alto, CA 94305, USA.
Matthew H SpitzerDepartment of Microbiology and Immunology and Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, USA.
Yaron CarmiDepartment of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Jiahan ChengDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Lorna L TolentinoDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Okmi ChoiDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Nancy WuDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Christina S KongDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University, Palo Alto, CA 94305, USA.
Andrew J GentlesDepartment of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Stanford University, Palo Alto, CA 94305, USA.
John B SunwooDepartment of Otolaryngology-Head & Neck Surgery, Stanford University, Palo Alto, CA 94305, USA; Stanford Cancer Institute, Stanford University, Palo Alto, CA 94305, USA.
Ansuman T SatpathyDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University, Palo Alto, CA 94305, USA; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.
Sylvia K PlevritisDepartment of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA; Department of Radiology, Stanford University, Palo Alto, CA 94305, USA.
Edgar G EnglemanDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University, Palo Alto, CA 94305, USA. Electronic address: edgareng@stanford.edu.
Stanford University · USTel Aviv University · IL

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Single-cell Mapping Center for Human Regulatory Elements and Gene ActivityUM1HG012076 · NHGRI · STANFORD UNIVERSITY · PI Michael Ryan Corces, Ansuman Satpathy · 2021 to 2026
$13.8M
Spatial-Genomic Integrative Multi-Species Analysis of Lymph Node MetastasisU54CA209971 · NCI · STANFORD UNIVERSITY · PI NOLAN, GARRY P, PLEVRITIS, SYLVIA KATINA · 2016 to 2021
$11.0M
Targeting Lymph Node Dependent Immune Tolerance in CancerR01CA251174 · NCI · STANFORD UNIVERSITY · PI EDGAR G. ENGLEMAN · 2021 to 2026
$3.2M
4DN Interrogation of T Cell Exhaustion in CancerU01CA260852 · NCI · STANFORD UNIVERSITY · PI SATPATHY, ANSUMAN · 2020 to 2024
$2.6M
Ultra high throughput sequencer for sustaining and enhancing multi-scale genomic studiesS10OD025212 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2018
$600k
Development of a glycopeptide vaccine for cancer metastasisF32CA189408 · NCI · STANFORD UNIVERSITY · PI RETICKER-FLYNN, NATHAN EDWARD · 2014 to 2016
$164k
Mechanistic basis of allogeneic IgG-induced tumor eradicationF31CA196029 · NCI · STANFORD UNIVERSITY · PI LINDE, IAN LISLE · 2015 to 2017
$127k
NCI NIH HHS F31 CA196029NCI NIH HHS F32 CA189408NCI NIH HHS P30 CA124435NCI NIH HHS R01 CA251174NCI NIH HHS U01 CA260852NCI NIH HHS U54 CA209971NHGRI NIH HHS UM1 HG012076NIDDK NIH HHS P30 DK116074NIH HHS S10 OD025212NLM NIH HHS T15 LM007033
6 · The paper itself

Abstract

For many solid malignancies, lymph node (LN) involvement represents a harbinger of distant metastatic disease and, therefore, an important prognostic factor. Beyond its utility as a biomarker, whether and how LN metastasis plays an active role in shaping distant metastasis remains an open question. Here, we develop a syngeneic melanoma mouse model of LN metastasis to investigate how tumors spread to LNs and whether LN colonization influences metastasis to distant tissues. We show that an epigenetically instilled tumor-intrinsic interferon response program confers enhanced LN metastatic potential by enabling the evasion of NK cells and promoting LN colonization. LN metastases resist T cell-mediated cytotoxicity, induce antigen-specific regulatory T cells, and generate tumor-specific immune tolerance that subsequently facilitates distant tumor colonization. These effects extend to human cancers and other murine cancer models, implicating a conserved systemic mechanism by which malignancies spread to distant organs.

Indexed as

Lymph NodesMelanomaAnimalsImmune ToleranceImmunotherapyLymphatic MetastasisMiceinterferonISGslymph nodesmetastasisMHC-INK cellsPD-L1regulatory T cellstoleranceTregs

Identifiers

PMID35525247
PMCPMC9149144
OpenAlexW4229005504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.