ArticleApplied microbiology and biotechnology2022
Antibacterial peptide NZ2114-loaded hydrogel accelerates Staphylococcus aureus-infected wound healing.
Article in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- In Vivo Wound Healing Effects of Antimicrobial Peptide-Based Dressings for S. aureus-Infected Wounds-A Systematic Review and Meta-Analysis.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
- Efficient Elimination of Microbial Infections in Wounds Using Plasma-Activated Water Hydrogel.ACS pharmacology & translational science · 2026Article
- Antimicrobial Peptides for Skin Wound Healing.Biomolecules · 2025Review
- Tailoring Self-Assembled Peptide Hydrogels with Antimicrobial or Cell Adhesive Properties for Tissue Engineering.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Hydrogel-Based Biointerfaces: Recent Advances, Challenges, and Future Directions in Human-Machine Integration.Gels (Basel, Switzerland) · 2025Review
- Application of Antimicrobial Peptides in Wound Dressings.Drug design, development and therapy · 2025Review
- Expression and characterization of the new antimicrobial peptide AP138L-arg26 anti Staphylococcus aureus.Applied microbiology and biotechnology · 2024Article
- Three in One with Dual-Functional Hydrogel of Lactoferrin/NZ2114/LMSH PromotingAntibiotics (Basel, Switzerland) · 2024Article
- Antibacterial Hydrogels for Wound Dressing Applications: Current Status, Progress, Challenges, and Trends.Gels (Basel, Switzerland) · 2024Review
- A Systematic Review of the Design and Applications of Antimicrobial Peptides in Wound Healing.Cureus · 2024Review
- Efficiency of NZ2114 on Superficial Pyoderma Infected withPharmaceuticals (Basel, Switzerland) · 2024Article
- Study on skin infection model ofHeliyon · 2023Article
- The contribution of immunohistochemistry to the development of hydrogels for skin repair and regeneration.European journal of histochemistry : EJH · 2023Review
- Antibacterial, injectable, and adhesive hydrogel promotes skin healing.Frontiers in bioengineering and biotechnology · 2023Article
- Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications.Materials (Basel, Switzerland) · 2022Review
- Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.Journal of inflammation research · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Wound infection caused by Staphylococcus aureus (S. aureus) is a great challenge which has caused significant burden and economic loss to the medical system. NZ2114, a plectasin-derived peptide, is an antibacterial agent for preventing and treating S. aureus infection, especially for methicillin-resistant S. aureus (MRSA) infection. Here, three-dimensional reticulated antimicrobial peptide (AMP) NZ2114 hydrogels were developed based on hydroxypropyl cellulose (HPC) and sodium alginate (SA); they displayed sustained and stable release properties (97.88 ± 1.79% and 91.1 ± 10.52% release rate in 72 h, respectively) and good short-term cytocompatibility and hemocompatibility. But the HPC-NZ2114 hydrogel had a smaller pore size (diameter 0.832 ± 0.420 μm vs. 3.912 ± 2.881 μm) and better mechanical properties than that of the SA-NZ2114 hydrogel. HPC/SA-NZ2114 hydrogels possess efficient antimicrobial activity in vitro and in vivo. In a full-thickness skin defect model, the wound closure of the 1.024 mg/g HPC-NZ2114 hydrogel group was superior to those of the SA-NZ2114 hydrogel and antibiotic groups on day 7. The HPC-NZ2114 hydrogel accelerated wound healing by reducing inflammation and promoting the production of vascular endothelial growth factor (VEGF), endothelial growth factor (EGF) and angiogenesis (CD31) through histological and immunohistochemistry evaluation. These data indicated that the HPC-NZ2114 hydrogel is an excellent candidate for S. aureus infection wound dressing. KEY POINTS: •NZ2114 hydrogels showed potential in vitro bactericidal activity against S. aureus •NZ2114 hydrogels could release continuously for 72 h and had good biocompatibility •NZ2114 hydrogels could effectively promote S. aureus-infected wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.