ArticleThe international journal of neuropsychopharmacology2022
Shared and Unique Effects of Long-Term Administration of Methylphenidate and Atomoxetine on Degree Centrality in Medication-Naïve Children With Attention-Deficit/Hyperactive Disorder.
Article in The international journal of neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder.Frontiers in psychiatry · 2022Pooled it
- The promoting effects of digital targeted cognitive training in medication treatment for children with ADHD: a randomized controlled trial.BMC medicine · 2025Trial
- Developmental deviations of association-network structural connectivity in youths with ADHD predict symptom and treatment outcomes.Nature biomedical engineering · 2026Article
- Altered voxel-wise degree centrality of brain networks in patients with chronic rhinosinusitis: a resting-state functional magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2025Article
- Effects of 4-Month Methylphenidate Treatment on Functional Connectivity in Attention-Deficit Hyperactivity Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Neuroimaging as a Tool for Advancing Pediatric Psychopharmacology.Paediatric drugs · 2025Review
- Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder.Translational psychiatry · 2025Article
- Effects of methylphenidate on children with attention deficit hyperactivity disorder: a study using clinical and multimodal approaches including go/no-go task and functional near-infrared spectroscopy.Frontiers in pharmacology · 2025Article
- Functional imaging derived ADHD biotypes based on deep clustering: a study on personalized medication therapy guidance.EClinicalMedicine · 2024Article
- Functional Imaging Derived ADHD Biotypes Based on Deep Clustering May Guide Personalized Medication Therapy.Research square · 2023Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough methylphenidate (MPH) and atomoxetine (ATX) can improve clinical symptoms and functional impairments in attention deficit/hyperactive disorder (ADHD), the underlying psychopharmacological mechanisms have not been clearly elucidated. Therefore, we aimed to explore the shared and unique neurologic basis of these 2 medications in alleviating the clinical symptoms and functional impairments observed in ADHD.
methodsSixty-seven ADHD and 44 age-matched children with typical development were included and underwent resting-state functional magnetic resonance imaging scans at baseline. Then patients were assigned to MPH, ATX, or untreated subgroups, based on the patients' and their parents' choice, for a 12-week follow-up and underwent a second functional magnetic resonance imaging scan. The treatment effect on degree centrality (DC) was identified and correlated with clinical symptoms and functional impairments in the ADHD group.
resultsBoth MPH and ATX normalized the DC value in extensive brain regions mainly involving fronto-cingulo-parieto-cerebellum circuits. However, ATX showed limited significant effects on the cerebellum compared with ADHD at baseline. The improvements in clinical symptoms were correlated with increased DC in the right inferior temporal gyrus in both MPH and ATX subgroups but showed opposite effects. The alleviation of functional impairments in the school/learning domain negatively correlated with decreased DC in the bilateral cerebellum after MPH treatment, and the family functional domain positively correlated with decreased DC in the cerebellum and negatively correlated with decreased DC in the postcentral gyrus after ATX treatment.
conclusionsBoth MPH and ATX can normalize abnormal brain functions that mainly involve the fronto-cingulo-parieto-cerebellum circuit in ADHD. Furthermore, the 2 medications showed shared and unique effects on brain functions to alleviate clinical symptoms and functional impairment.
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