ArticleJournal of veterinary internal medicine2022
Evaluation of adverse events in small-breed dogs treated with maropitant and a single dose of doxorubicin.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Long-term management of mandibular osteosarcoma in a dog using toceranib after hemimandibulectomy.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- A rapid state-of the-art review of client-reported outcomes measures used to assess dogs' clinical signs and quality of life during chemotherapy.BMC veterinary research · 2025Review
- Evaluation of adverse events in small-breed dogs treated with maropitant and a single dose of doxorubicin.Journal of veterinary internal medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe recommended doxorubicin (DOX) dose for small dogs is 1 mg/kg. Recent data suggest that DOX-induced gastrointestinal (GI) toxicosis can be reduced with maropitant treatment.
objectivesTo investigate the incidence of adverse events (AEs) in small-breed dogs administered a single 25 mg/m ANIMALS: Nineteen small-breed tumor-bearing dogs.
methodsA prospective, observational study of tumor-bearing dogs, weighing 5 to 10 kg, administered a single 25 mg/m
resultsInappetence, vomiting, and diarrhea were found in 7/19, 2/19, and 6/19 of the DOX25 dogs, respectively. Neutropenia and thrombocytopenia was 12/19 and 3/19, respectively. Most AEs were grades 1 and 2, except for grades 3 and 4 inappetence and neutropenia in 3 and 4 dogs, respectively. Furthermore, febrile neutropenia occurred in 3/19 dogs in the DOX25 group. All AEs between the DOX25 and historical control groups were not significantly different. CONCLUSIONS AND CLINICAL IMPORTANCE: Vomiting and diarrhea were deemed acceptable with 25 mg/m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.