ArticleJournal of clinical laboratory analysis2022
A U-shaped association between serum albumin with total triiodothyronine in adults.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Association between impaired peripheral thyroid hormone sensitivity and coronary heart disease in type 2 diabetes: the potential mediating role of albumin.Frontiers in endocrinology · 2026Article
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- Association Between Dietary Alcohol Intake and Migraine or Severe Headache Miscellaneous Pain: The NHANES 1999-2004.Brain and behavior · 2025Article
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- Association of weight-adjusted waist index with all-cause mortality among non-Asian individuals: a national population-based cohort study.Nutrition journal · 2024Article
- The association between weight-adjusted-waist index and stress urinary incontinence in female adults: a population-based study.International urology and nephrology · 2024Article
- Associations of cereal fiber intake with rheumatoid arthritis mediated by dietary inflammatory index: insights from NHANES 2011-2020.Scientific reports · 2024Article
- Association between blood total mercury and psoriasis: The NHANES 2005-2006 and 2013-2014: A cross-sectional study.PloS one · 2024Article
- Associations between systemic immune-inflammatory index and visceral adipose tissue area: results of a national survey.Frontiers in nutrition · 2024Article
- Dietary inflammatory potential and biological aging among US adults: a population-based study.Aging clinical and experimental research · 2023Article
- Associations between weight-adjusted waist index and fractures: a population-based study.Journal of orthopaedic surgery and research · 2023Article
- BMI, socioeconomic status, and bone mineral density in U.S. adults: Mediation analysis in the NHANES.Frontiers in nutrition · 2023Article
- Article
- Association of family income to poverty ratio and vibration-controlled transient elastography quantified degree of hepatic steatosis in U.S. adolescents.Frontiers in endocrinology · 2023Article
- A U-shaped association between serum albumin with total triiodothyronine in adults.Journal of clinical laboratory analysis · 2022Article
- The Tri-iodothyronine (T3) Level Is a Prognostic Factor for Patients With Advanced NSCLC: Receiving Immune Checkpoint Inhibitors and Is Associated With Liver Metastasis.Clinical Medicine Insights. Oncology · 2022Article
- Inverse association between low-density lipoprotein cholesterol and bone mineral density in young- and middle-aged people: The NHANES 2011-2018.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThyroid dysfunction is a common thyroid disorder in our life and its symptoms are non-specific, therefore the diagnosis of thyroid dysfunction is important for patients. Albumin (ALB) can carry thyroid hormones to their sites of action as a way to achieve rapid delivery of thyroid hormones to the tissues. The purpose of this study was to investigate the relationship between serum ALB levels and total triiodothyronine (TT3) in adults.
methodsData from the 2007-2012 National Health and Nutrition Examination Survey (NHANES) were used to examine the association between ALB and TT3 using multivariate logistic regression models. Fitting smoothed curves and generalized weighted models were also used.
resultsThe analysis included a total of 7933 participants that we found an independent positive relationship between ALB and TT3 among participants [0.006 (0.003, 0.009)]. In men, there was a significant positive correlation between ALB and TT3, whereas in women ALB and TT3 suggested a significant negative correlation. Moreover, our study revealed that the independent association between the levels of ALB and TT3 was significant in Non-Hispanic White, but not in Non-Hispanic Black. Notably, we found a U-shaped association between ALB and serum TT3 in total participants (inflection point for ALB: 41 g/L) and females after adjusted covariates (inflection point for ALB: 46 g/L).
conclusionsWe found a U-shaped relationship between serum ALB and TT3 with infection point at 41 g/L for ALB, which may provide a reference for future screening in adults with thyroid dysfunction.
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