Evidence map›Paper›PMID 35524328›Full record

SynthesisBMC health services research2022

Contributing factors to healthcare costs in individuals with autism spectrum disorder: a systematic review.

Behzad Karami Matin, Sarah Byford, Shahin Soltani, Ali Kazemi-Karyani, Zahra Atafar, Ehsan Zereshki, Moslem Soofi, Satar Rezaei, Shiva Tolouei Rakhshan, Parvin Jahangiri

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in BMC health services research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Prenatal exposure to extreme heat and autism in children.The Science of the total environment · 2026
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  9. Material hardship and sources of support for autistic adolescents and their families.Autism : the international journal of research and practice · 2025
    Article
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  11. Review
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  13. Review
  14. Article
  15. Machine Learning Differentiation of Autism Spectrum Sub-Classifications.Journal of autism and developmental disorders · 2024
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Behzad Karami MatinResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID https://orcid.org/0000-0002-8432-2079
Sarah ByfordKing's College London, London, UK.ORCID https://orcid.org/0000-0001-7084-1495
Shahin SoltaniResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. shahin.soltani@kums.ac.ir.ORCID https://orcid.org/0000-0001-8365-7363
Ali Kazemi-KaryaniResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID https://orcid.org/0000-0002-4448-9317
Zahra AtafarSocial Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID https://orcid.org/0000-0002-0046-5962
Ehsan ZereshkiResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Moslem SoofiSocial Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID https://orcid.org/0000-0003-4922-8412
Satar RezaeiResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.ORCID https://orcid.org/0000-0002-6194-6057
Shiva Tolouei RakhshanResearch Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Parvin JahangiriBehavioral Disease Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Kermanshah University of Medical Sciences · IRKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndividuals with autism spectrum disorder (ASD) are more likely to use healthcare than their counterparts without disabilities, which imposes high medical costs to families and health systems. This study aimed to investigate healthcare costs and its determinants among individuals with ASD.

methodsIn this systematic review, we searched online databases (Web of Science, Medline through PubMed and Scopus) for observational and experimental studies that included data on service use and costs associated with ASD and published between January 2000 and May 2021. Exclusion criteria included non-English language articles, duplicates, abstracts, qualitative studies, gray literature, and non-original papers (e.g., letters to editors, editorials, reviews, etc.).

resultsOur searches yielded 4015 articles screened according to PRISMA guidelines. Of 4015 studies identified, 37 articles from 10 countries were eligible for final inclusion. Therapeutic interventions, outpatient visits and medications constituted the largest proportion of direct medical expenditure on individuals with ASD. Included studies suggest lack of health insurance, having associated morbidities, more severe symptoms, younger age groups and lower socioeconomic status (SES) are associated with higher medical expenditure in individuals with ASD.

conclusionsThis systematic review identified a range of factors, including lower SES and lack of health insurance, which are associated with higher healthcare costs in people with ASD. Our study supports the formulation of policy options to reduce financial risks in families of individuals with ASD in countries which do not have a tax-based or universal health coverage system.

Indexed as

Autism Spectrum DisorderHealth Care CostsHealth ExpendituresHumansInsurance, HealthQualitative ResearchAutismDeterminantsHealthcare costsOut of pocket paymentsSystematic review

Identifiers

PMID35524328
PMCPMC9074281
OpenAlexW4229069484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.