ArticleBiotechnology for biofuels and bioproducts2022
Engineering proton-coupled hexose uptake in Saccharomyces cerevisiae for improved ethanol yield.
Article in Biotechnology for biofuels and bioproducts, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 19 citations in OpenAlex.
- Characterization of three glycerol transporters with broad sugar specificities from Aspergillus niger.Applied microbiology and biotechnology · 2026Article
- Structural and biochemical insights of xylose MFS and SWEET transporters in microbial cell factories: challenges to lignocellulosic hydrolysates fermentation.Frontiers in microbiology · 2024Review
- FromJournal of fungi (Basel, Switzerland) · 2023Review
- Improved Sugarcane-Based Fermentation Processes by an Industrial Fuel-Ethanol Yeast Strain.Journal of fungi (Basel, Switzerland) · 2023Article
- Synthetic biology promotes the capture of CO2 to produce fatty acid derivatives in microbial cell factories.Bioresources and bioprocessing · 2022Review
- Novel Evolutionary Engineering Approach to Alter Substrate Specificity of Disaccharide Transporter Mal11 inJournal of fungi (Basel, Switzerland) · 2022Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundIn the yeast Saccharomyces cerevisiae, which is widely applied for industrial bioethanol production, uptake of hexoses is mediated by transporters with a facilitated diffusion mechanism. In anaerobic cultures, a higher ethanol yield can be achieved when transport of hexoses is proton-coupled, because of the lower net ATP yield of sugar dissimilation. In this study, the facilitated diffusion transport system for hexose sugars of S. cerevisiae was replaced by hexose-proton symport.
resultsIntroduction of heterologous glucose- or fructose-proton symporters in an hxt
conclusionsThis study provides a proof-of-concept for the replacement of the endogenous hexose transporters of S. cerevisiae by hexose-proton symport, and the concomitant decrease in ATP yield, to greatly improve the anaerobic yield of ethanol on sugar. Moreover, the sugar-negative platform strain constructed in this study acts as a valuable starting point for future studies on sugar transport or development of cell factories requiring specific sugar transport mechanisms.
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