Evidence map›Paper›PMID 35524288›Full record

ArticleJournal of pineal research2022

Melatonin modulates Nrf2 activity to protect porcine pre-pubertal Sertoli cells from the abnormal H

Desirée Bartolini, Iva Arato, Francesca Mancuso, Daniela Giustarini, Catia Bellucci, Carmine Vacca, Maria Chiara Aglietti, Anna Maria Stabile, Ranieri Rossi, Gabriele Cruciani and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of pineal research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Desirée BartoliniDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.ORCID http://orcid.org/0000-0003-3849-757X
Iva AratoDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Francesca MancusoDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Daniela GiustariniDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Catia BellucciDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Carmine VaccaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Maria Chiara AgliettiDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Anna Maria StabileDepartment of Medicine and Surgery, Section of Human, Clinical and Forensic Anatomy, University of Perugia, Perugia, Italy.
Ranieri RossiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Gabriele CrucianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Mario RendeDepartment of Medicine and Surgery, Section of Human, Clinical and Forensic Anatomy, University of Perugia, Perugia, Italy.
Riccardo CalafioreDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Giovanni LucaDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Francesco GalliDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.ORCID http://orcid.org/0000-0003-3626-051X
University of Perugia · ITUniversity of Siena · IT

Funding

Fondazione Cassa di Risparmio di PerugiaMinistero dell'Istruzione, dell'Università e della Ricerca
6 · The paper itself

Abstract

Melatonin (MLT) is a cytoprotective agent holding potential to prevent cadmium (Cd) toxicity and its impact in testicular function and fertility. In this study, we explored such potential in porcine pre-pubertal Sertoli cells (SCs). Cd toxicity resulted in impaired SC viability and function, abnormal cellular H

Indexed as

MelatoninNF-E2-Related Factor 2AnimalsCadmiumCystineGlutathioneMaleOxidative StressProto-Oncogene Proteins c-aktSertoli CellsSwineCadmiumCystineGlutathioneMelatoninNF-E2-Related Factor 2Proto-Oncogene Proteins c-aktcadmiumglutathionemelatoninNFkBNrf2reductive stressSertoli cells

Identifiers

PMID35524288
PMCPMC9539639
OpenAlexW4229010940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.