ArticleJournal of neurodevelopmental disorders2022
The electroretinogram b-wave amplitude: a differential physiological measure for Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder.
Article in Journal of neurodevelopmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Retinal GABAergic Alterations in Adults with Autism Spectrum Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Trial
- ERG-Graph: Graph Signal Processing of the Electroretinogram for Classification of Neurodevelopmental Disorders.Bioengineering (Basel, Switzerland) · 2026Article
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Technical note: contour plot visualization of the light adapted electroretinogram using a generalized additive model.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Development and psychometric validation of a novel, self-report visual processing questionnaire (ViPro-SR) for neurodivergent adults.Current psychology (New Brunswick, N.J.) · 2026Article
- Electroretinography as a non-invasive biomarker for early detection of cognitive impairment in older adults: A scoping review protocol.PloS one · 2026Article
- Synthetic electroretinogram signal generation using a conditional generative adversarial network.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Global motion coherent deficits in individuals with autism spectrum disorder and their family members are associated with retinal function.Scientific reports · 2025Article
- Electroretinographic Findings in Fragile X, Premutation, and Controls: A Study of Biomarker Correlations.International journal of molecular sciences · 2025Article
- Cognitive function and retinal biomarkers as novel approach to diagnosing and assessing autism spectrum disorder.Scientific reports · 2025Article
- Retinal fundus imaging as biomarker for ADHD using machine learning for screening and visual attention stratification.NPJ digital medicine · 2025Article
- Brief report: effects of methylphenidate on the light adapted electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- The electroretinography to identify biomarkers of idiopathic hypersomnia and narcolepsy type 1.Journal of sleep research · 2025Article
- Remodeling the light-adapted electroretinogram using a bayesian statistical approach.BMC research notes · 2025Article
- Ocular manifestations in autism spectrum disorder.International journal of ophthalmology · 2025Review
- Spectral Analysis of Light-Adapted Electroretinograms in Neurodevelopmental Disorders: Classification with Machine Learning.Bioengineering (Basel, Switzerland) · 2024Article
- The prion protein is required for normal responses to light stimuli by photoreceptors and bipolar cells.iScience · 2024Article
- Generating Synthetic Light-Adapted Electroretinogram Waveforms Using Artificial Intelligence to Improve Classification of Retinal Conditions in Under-Represented Populations.Journal of ophthalmology · 2024Article
- Group comparisons of the individual electroretinogram time trajectories for the ascending limb of the b-wave using a raw and registered time series.BMC research notes · 2023Article
- Visual electrophysiology and "the potential of the potentials".Eye (London, England) · 2023Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAttention Deficit Hyperactivity Disorder (ADHD) is the most prevalent childhood neurodevelopmental disorder. It shares some genetic risk with Autism Spectrum Disorder (ASD), and the conditions often occur together. Both are potentially associated with abnormal glutamate and GABA neurotransmission, which can be modelled by measuring the synaptic activity in the retina with an electroretinogram (ERG). Reduction of retinal responses in ASD has been reported, but little is known about retinal activity in ADHD. In this study, we compared the light-adapted ERGs of individuals with ADHD, ASD and controls to investigate whether retinal responses differ between these neurodevelopmental conditions.
methodsFull field light-adapted ERGs were recorded from 15 ADHD, 57 ASD (without ADHD) and 59 control participants, aged from 5.4 to 27.3 years old. A Troland protocol was used with a random series of nine flash strengths from -0.367 to 1.204 log photopic cd.s.m
resultsStatistically significant elevations of the ERG b-wave amplitudes, PhNR responses and faster timings of the b-wave time-to-peak were found in those with ADHD compared with both the control and ASD groups. The greatest elevation in the b-wave amplitudes associated with ADHD were observed at 1.204 log phot cd.s.m
conclusionsThe ERG b-wave amplitude appears to be a distinctive differential feature for both ADHD and ASD, which produced a reversed pattern of b-wave responses. These findings imply imbalances between glutamate and GABA neurotransmission which primarily regulate the b-wave formation. Abnormalities in the b-wave amplitude could provisionally serve as a biomarker for both neurodevelopmental conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.