Evidence map›Paper›PMID 35524158›Full record

ArticleScientific reports2022

Associations of intracranial artery length and branch number on non-contrast enhanced MRA with cognitive impairment in individuals with carotid atherosclerosis.

Zhensen Chen, Anders Gould, Duygu Baylam Geleri, Niranjan Balu, Li Chen, Baocheng Chu, Kristi Pimentel, Gador Canton, Thomas S Hatsukami, Chun Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhensen ChenVascular Imaging Laboratory, Department of Radiology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, 98109, USA. zhensenchen@gmail.com.
Anders GouldCarle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
Duygu Baylam GeleriVascular Imaging Laboratory, Department of Radiology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, 98109, USA.
Niranjan BaluVascular Imaging Laboratory, Department of Radiology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, 98109, USA.
Li ChenDepartment of Electrical and Computer Engineering, University of Washington, Seattle, WA, USA.
Baocheng ChuVascular Imaging Laboratory, Department of Radiology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, 98109, USA.
Kristi PimentelVascular Imaging Laboratory, Department of Radiology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, 98109, USA.
Gador CantonVascular Imaging Laboratory, Department of Radiology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, 98109, USA.
Thomas S HatsukamiDepartment of Surgery, University of Washington, Seattle, WA, USA.
Chun YuanVascular Imaging Laboratory, Department of Radiology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, 98109, USA.

Funding

Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical SequelaeR01HL103609 · NHLBI · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS, YUAN, CHUN · 2011 to 2021
$7.1M
3D WALLI: MR intracranial vessel wall imaging for stroke preventionR01NS092207 · NINDS · UNIVERSITY OF WASHINGTON · PI MOSSA-BASHA, MAHMUD, YUAN, CHUN · 2016 to 2019
$3.1M
NHLBI NIH HHS R01 HL103609NIH HHS R01NS092207; R01HL103609NINDS NIH HHS R01 NS092207
6 · The paper itself

Abstract

Developing novel risk markers for vascular contributions to cognitive impairment and dementia is important. This study aimed to extract total length, branch number and average tortuosity of intracranial distal arteries (A2, M2, P2 and more distal) from non-contrast enhanced magnetic resonance angiography (NCE-MRA) images, and explore their associations with global cognition. In 29 subjects (aged 40-90 years) with carotid atherosclerotic disease, the 3 intracranial vascular features on two NCE-MRA techniques (i.e. time of flight, TOF and simultaneous non-contrast angiography and intraplaque hemorrhage, SNAP) were extracted using a custom-developed software named iCafe. Arterial spin labeling (ASL) and phase contrast (PC) cerebral blood flow (CBF) were measured as references. Linear regression was performed to study their associations with global cognition, measured with the Montreal Cognitive Assessment (MoCA). Intracranial artery length and number of branches on NCE-MRA, ASL CBF and PC CBF were found to be positively associated with MoCA scores (P < 0.01). The associations remained significant for artery length and number of branches on NCE-MRA after adjusting for clinical covariates and white matter hyperintensity volume. Further adjustment of confounding factors of ASL CBF or PC CBF did not abolish the significant association for artery length and number of branches on TOF. Our findings suggest that intracranial vascular features, including artery length and number of branches, on NCE-MRA may be useful markers of cerebrovascular health and provide added information over conventional brain blood flow measurements in individuals with cognitive impairment.

Indexed as

Carotid Artery DiseasesCognitive DysfunctionArteriesHumansMagnetic Resonance AngiographySpin LabelsSpin Labels

Identifiers

PMID35524158
PMCPMC9076596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.