ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2022
Cardioinhibitory syncope with asystole during nitroglycerin potentiated head up tilt test: prevalence and clinical predictors.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Value of demographic factors in early identification of pediatric malignant vasovagal syncope in head-up tilt test.Clinical and experimental pediatrics · 2026Article
- Pediatric reflex syncope: updated insights and future directions.European journal of pediatrics · 2026Review
- The Evolution of Head-Upright Tilt-Table Testing in Toronto, Ontario, Canada: 2014-2024.CJC open · 2025Article
- Mechanism of syncope: role of ambulatory blood pressure monitoring and cardiovascular autonomic function assessment.European heart journal · 2025Observational
- Malignant vasovagal syncope in children.World journal of pediatrics : WJP · 2025Review
- Asystole on loop recorder in patients with unexplained syncope and negative tilt testing: age distribution and clinical predictors.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Vasovagal Syncope at Work: A Narrative Review for an Occupational Management Proposal.International journal of environmental research and public health · 2023Review
- Prevalence of asystole during tilt test-induced vasovagal syncope may depend on test methodology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Review
- Development of a nomogram model to predict malignant vasovagal syncope in Chinese children.Frontiers in pediatrics · 2023Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of our study was to evaluate the prevalence and clinical predictors of cardioinhibitory (CI) responses with asystole at the nitroglycerin (NTG)-potentiated head-up tilt test (HUTT) in patients with a history of syncope admitted to a tertiary referral syncope unit.
methodsWe retrospectively evaluated all consecutive patients who underwent NTG-potentiated HUTT for suspected reflex syncope at our institution from March 1 2017 to May 1 2020. The prevalence of HUTT-induced CI syncope was assessed. Univariate and multivariate analyses were performed to test the association of asystolic response to HUTT with a set of clinical covariates.
resultsWe enrolled 1285 patients (45 ± 19.1 years; 49.6% male); 368 (28.6%) showed HUTT-induced CI response with asystole. A multivariate analysis revealed that the following factors were independently associated with HUTT-induced CI syncope: male sex (OR 1.48; ConInt 1.14-1.92; P = 0.003), smoking (OR 2.22; ConInt 1.56-3.115; P < 0.001), traumatic syncope (OR: 2.81; ConInt 1.79-4.42; P < 0.001), situational syncope (OR 0.45; ConInt 0.27-0.73; P = 0.002), and the use of diuretics (OR 9.94; ConInt 3.83-25.76; P < 0.001).
conclusionsThe cardioinhibitory syncope with asystole induced by NTG-potentiated HUTT is more frequent than previously reported. The male gender, smoking habit, history of traumatic syncope, and use of diuretics were independent predictors of HUTT-induced CI responses. Conversely, the history of situational syncope seems to reduce this probability.
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